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Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling
The results indicate that different Wnt/Fz signals activate distinct intracellular pathways, and Dishevelled discriminates among them by distinct domain interactions, and the planar polarity-specific dsh1 allele is mutated in the DEP domain.
REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
It is proposed that expression of the type II sodium channel gene in neurons reflects a default pathway that is blocked in nonneuronal cells by the presence of REST.
A global genetic interaction network maps a wiring diagram of cellular function
- M. Costanzo, Benjamin VanderSluis, +51 authors Charles Boone
- Biology, MedicineScience
- 23 September 2016
A global genetic interaction network highlights the functional organization of a cell and provides a resource for predicting gene and pathway function and how coherent sets of negative or positive genetic interactions connect protein complex and pathways to map a functional wiring diagram of the cell.
Sequential activation of signaling pathways during innate immune responses in Drosophila.
Genome-wide expression profiling was used to analyze the outcome of impairing specific signaling pathways after microbial challenge and found that these transcriptional patterns can be dissected into distinct groups, suggesting that innate immune responses are modular and recruit distinct physiological programs.
Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.
- H. Agaisse, U. Petersen, M. Boutros, B. Mathey-Prevot, N. Perrimon
- Biology, MedicineDevelopmental cell
- 1 September 2003
This study reveals that, in addition to the pattern recognition receptor-mediated NF-KB-dependent immune response, Drosophila undergoes a complex systemic response that is mediated by the production of cytokines in blood cells, a process that is similar to the acute phase response in mammals.
Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset
- Sung E. Choe, M. Boutros, A. Michelson, G. Church, M. Halfon
- Biology, MedicineGenome Biology
- 28 January 2005
A best-route combination of analysis methods is presented that allows detection of approximately 70% of true positives before reaching a 10% false-discovery rate, and highlights areas in need of improvement, including better estimate of false-Discovery rates and decreased false-negative rates.
Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein
It is suggested that evi is the founding member of a gene family specifically required for Wg/Wnt secretion, which is evolutionarily conserved as depletion of its human homolog disrupts Wnt signaling in human cells.
Requirement of Prorenin Receptor and Vacuolar H+-ATPase–Mediated Acidification for Wnt Signaling
The results reveal an unsuspected role for the prorenin receptor, V-ATPase activity, and acidification during Wnt/β-catenin signaling.
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
- A. Eulalio, J. Rehwinkel, +7 authors E. Izaurralde
- Biology, MedicineGenes & development
- 15 October 2007
It is suggested that miRNAs mediate post-transcriptional gene silencing by more than one mechanism, as in the absence of active translation, some miRNA targets are stabilized, whereas others continue to be degraded in a miRNA-dependent manner.
Genome-Wide RNAi Analysis of Growth and Viability in Drosophila Cells
A high-throughput RNA-interference screen of 19,470 double-stranded RNAs in cultured cells to characterize the function of nearly all predicted Drosophila genes in cell growth and viability found 438 dsRNAs that identified essential genes, among which 80% lacked mutant alleles.