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CDC73 gene

Known as: HRPT2, HYRAX, DROSOPHILA, HOMOLOG OF, HYX 
This gene is involved in transcription and may play a role in cell cycle progression.
National Institutes of Health

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CDC73 wt Allele
Cell Cycle ControlHYPERPARATHYROIDISM 1HYPERPARATHYROIDISM 3Hyperparathyroidism-Jaw Tumor Syndrome

Papers overview

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2015
2015
Parafibromin Staining Characteristics in Urothelial Carcinomas and Relationship with Prognostic Parameters
Background: Parafibromin is a recently defined tumor suppressor gene. The aim of our study was to determine the relationships of… 
2013
2013
Transcriptional Repression of Tumor Suppressor CDC73, Encoding an RNA Polymerase II Interactor, by Wilms Tumor 1 Protein (WT1) Promotes Cell Proliferation
Background: Physiological targets of WT1 and the mechanism by which its up-regulation leads to neoplastic transformation remain… 
Highly Cited
2012
Highly Cited
2012
Parafibromin immunohistochemical staining to differentiate parathyroid carcinoma from parathyroid adenoma
Parafibromin is a protein encoded by the HRPT2 oncosuppressor gene, and the expression is reported to be decreased or absent in… 
2011
2011
Absence of nucleolar parafibromin immunoreactivity in subsets of parathyroid malignant tumours
Hyperparathyroidism 2 (HRPT2) gene mutations underlie hereditary and sporadic forms of primary hyperparathyroidism (PHPT), and… 
2010
2010
Parafibromin as a Diagnostic Instrument for Parathyroid Carcinoma-Lone Ranger or Part of the Posse?
The diagnosis of parathyroid carcinoma requires an invasive growth pattern or metastases detected at histopathological… 
Review
2008
Review
2008
Challenging Lesions in the Differential Diagnosis of Endocrine Tumors: Parathryoid Carcinoma
Parathyroid neoplasms encompass a spectrum of proliferative lesions that include adenomas, atypical adenomas, and carcinomas… 
2007
2007
Nucleolar localization of parafibromin is mediated by three nucleolar localization signals
2007
2007
Identification of a functional bipartite nuclear localization signal in the tumor suppressor parafibromin
2005
2005
Identification of a functional bipartite nuclear localization signal in the tumor suppressor parafibromin
Parafibromin is a putative tumor suppressor encoded by HRPT2, mutations in which have been implicated in the familial tumor… 
Review
2004
Review
2004
Renal neoplasia in the hyperparathyroidism-jaw tumor syndrome.
Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a familial multi-tumor syndrome resulting from mutations in the HRPT2 tumor… 
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