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CDC73 gene

Known as: HRPT2, HYRAX, DROSOPHILA, HOMOLOG OF, HYX 
This gene is involved in transcription and may play a role in cell cycle progression.
National Institutes of Health

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CDC73 wt Allele
Cell Cycle ControlHYPERPARATHYROIDISM 1HYPERPARATHYROIDISM 3Hyperparathyroidism-Jaw Tumor Syndrome

Papers overview

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Highly Cited
2018
Highly Cited
2018
Parafibromin-deficient (HPT-JT Type, CDC73 Mutated) Parathyroid Tumors Demonstrate Distinctive Morphologic Features
The gene CDC73 (previously known as HRPT2) encodes the protein parafibromin. Biallelic mutation of CDC73 is strongly associated… 
Highly Cited
2009
Highly Cited
2009
Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma.
CONTEXT Parafibromin, encoded by HRPT2, is the first marker with significant benefit in the diagnosis of parathyroid carcinoma… 
Highly Cited
2007
Highly Cited
2007
Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma?
OBJECTIVE HRPT2 gene mutations are associated with parathyroid carcinomas, and absence of parafibromin immunoreactivity has been… 
Highly Cited
2007
Highly Cited
2007
Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification.
Parafibromin is a protein product derived from the hyperparathyroidism 2(HRPT2) tumor suppressor geneand its inactivation has… 
Highly Cited
2006
Highly Cited
2006
Parafibromin/Hyrax Activates Wnt/Wg Target Gene Transcription by Direct Association with β-catenin/Armadillo
Highly Cited
2006
Highly Cited
2006
Loss of Nuclear Expression of Parafibromin Distinguishes Parathyroid Carcinomas and Hyperparathyroidism-Jaw Tumor (HPT-JT) Syndrome-related Adenomas From Sporadic Parathyroid Adenomas and…
Parathyroid carcinoma is notoriously difficult to diagnose with confidence in borderline cases. Commonly there is a long lag time… 
Highly Cited
2006
Highly Cited
2006
HRPT2 gene alterations in ossifying fibroma of the jaws.
Highly Cited
2005
Highly Cited
2005
The HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II
ABSTRACT Inactivation of the HRPT2 tumor suppressor gene is associated with the pathogenesis of the hereditary… 
Highly Cited
2003
Highly Cited
2003
HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours
Background: Hyperparathyroidism is a common endocrinopathy characterised by the formation of parathyroid tumours. In this study… 
Highly Cited
1999
Highly Cited
1999
A Complex Containing RNA Polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p Plays a Role in Protein Kinase C Signaling
ABSTRACT Yeast contains at least two complex forms of RNA polymerase II (Pol II), one including the Srbps and a second… 
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