Absence of nucleolar parafibromin immunoreactivity in subsets of parathyroid malignant tumours

@article{Juhlin2010AbsenceON,
  title={Absence of nucleolar parafibromin immunoreactivity in subsets of parathyroid malignant tumours},
  author={C Christofer Juhlin and Felix Haglund and Takao Obara and Andrew Arnold and Catharina Larsson and Anders H{\"o}{\"o}g},
  journal={Virchows Archiv},
  year={2010},
  volume={459},
  pages={47-53}
}
Hyperparathyroidism 2 (HRPT2) gene mutations underlie hereditary and sporadic forms of primary hyperparathyroidism (PHPT), and the encoded product parafibromin has been established as a marker for facilitating parathyroid tumour classification. HRPT2 mutations and reduced nuclear expression of parafibromin are readily observed in parathyroid carcinomas but rarely in benign tumours, thereby aiding the identification of malignant PHPT. Recently, parafibromin has been shown to localize to the… CONTINUE READING