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CDC37 homolog protein

Known as: p50Cdc37, Hsp90 Co-Chaperone CDC37, CDC37 Homolog 
Hsp90 co-chaperone Cdc37 (378 aa, ~44 kDa) is encoded by the human CDC37 gene. This protein is involved in post-translational protein targeting.
National Institutes of Health

Related topics

Related topics

7 relations
CDC37 geneCell Cycle ControlHomo sapiensSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Functional and physical interaction between yeast Hsp90 and Hsp70
Significance The Hsp90 molecular chaperone remodels and activates a large variety of client proteins. Its activity requires… 
Highly Cited
2008
Highly Cited
2008
Hsp90-Dependent Activation of Protein Kinases Is Regulated by Chaperone-Targeted Dephosphorylation of Cdc37
Review
2008
Review
2008
Targeting the oncogene and kinome chaperone CDC37
CDC37 is a molecular chaperone that physically stabilizes the catalytic domains found in protein kinases and is therefore a wide… 
Highly Cited
2003
Highly Cited
2003
A Positive Feedback Loop between Protein Kinase CKII and Cdc37 Promotes the Activity of Multiple Protein Kinases*
We report here the identification ofCDC37, which encodes a putative Hsp90 co-chaperone, as a multicopy suppressor of a… 
Review
1998
Review
1998
The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors
  • W. Pratt
  • Proceedings of the Society for Experimental…
  • 1998
  • Corpus ID: 6846783
Abstract A variety of transcription factors and protein kinases involved in signal transduction are recovered from cells in… 
Highly Cited
1998
Highly Cited
1998
Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells
We have performed biochemical analyses of cdk6 complexes in T cells. By gel filtration chromatography we observed at least three… 
Highly Cited
1997
Highly Cited
1997
Interaction between Cdc37 and Cdk4 in human cells
Using the yeast two-hybrid system we have identified novel potential Cdk4 interacting proteins. Here we described the interaction… 
Highly Cited
1996
Highly Cited
1996
Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
CDC37, an essential gene in Saccharomyces cerevisiae, interacts genetically with multiple protein kinases and is required for… 
Highly Cited
1996
Highly Cited
1996
Physical Interaction of Mammalian CDC37 with CDK4*
CDC37 was originally identified as a Start gene in budding yeast and has been shown to be required for association of CDC28 with… 
Highly Cited
1995
Highly Cited
1995
Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins.
Studies of the temperature-sensitive cdc37-1 mutant of Saccharomyces cerevisiae suggest that Cdc37 is required for passage… 
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