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CD8 Antigen, Beta Polypeptide 1

Known as: CD8B, T-Cell Surface Glycoprotein CD8 Beta Chain, LYT3 
T-cell surface glycoprotein CD8 beta chain (210 aa, ~24 kDa) is encoded by the human CD8B gene. This protein plays a role in T-cell cytotoxicity.
National Institutes of Health

Related topics

Related topics

15 relations
CD8 AntigensCD8A geneCD8B geneCD8B wt Allele
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Papers overview

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Highly Cited
2015
Highly Cited
2015
Transcriptomic correlates of organ failure extent in sepsis.
OBJECTIVES Sepsis is characterised by the frequent presence of organ failure and marked immunologic alterations. We studied the… Expand
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2015
2015
The DNA methylation signature of human TCRαβ+CD4-CD8- double negative T cells reveals CG demethylation and a unique epigenetic architecture permissive to a broad stimulatory immune response.
T cell receptor (TCR) αβ+CD4-CD8- double negative T cells represent a rare T cell subset implicated in the pathogenesis of… Expand
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2014
2014
Transcriptome analysis reveals an activation of major histocompatibility complex 1 and 2 pathways in chicken trachea immunized with infectious laryngotracheitis virus vaccine.
Infectious laryngotracheitis is an acute, contagious, upper respiratory disease of chickens caused by gallid herpes virus 1. Due… Expand
Review
2013
Review
2013
Transcriptional control of CD4 and CD8 coreceptor expression during T cell development
The differentiation and function of peripheral helper and cytotoxic T cell lineages is coupled with the expression of CD4 and CD8… Expand
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Review
2011
Review
2011
The golden anniversary of the thymus
Nature Reviews Immunology 11, 489–495 (2011) In the original version of this article, in the section under the title “Lymphocyte… Expand
Highly Cited
2006
Highly Cited
2006
Negative regulation of CD8 expression via Cd8 enhancer–mediated recruitment of the zinc finger protein MAZR
Coreceptor expression is tightly regulated during thymocyte development. Deletion of specific Cd8 enhancers leads to variegated… Expand
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2004
2004
Identification of key immune mediators regulating T helper 1 responses in swine.
This publication describes the cloning of full or partial length sequences for pig TBX21 (T-bet), MYD88, ICSBP1, CD8A (CD8alpha… Expand
2004
2004
Evaluation of the circulating and splenic lymphocyte subpopulations in patients with non-hodgkin lymphomas and Hodgkin's disease using monoclonal antibodies
SummaryThe number of B lymphocytes, T lymphocytes and their helper/inducer, cytotoxic/suppressor and NK/K subpopulations was… Expand
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Review
2002
Review
2002
Decision making in the immune system: Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation
The regulation of gene expression during thymocyte development provides an ideal experimental system to study lineage-commitment… Expand
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1983
1983
Phenotypes of human large granular lymphocytes as defined by monoclonal antibodies.
Four monoclonal antibodies VEP8, VEP9, VIM-D5, VIB-C5 against antigens expressed on human mature myeloid cells (polymorphonuclear… Expand
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