CD8 Antigen, Beta Polypeptide 1

Known as: CD8B, T-Cell Surface Glycoprotein CD8 Beta Chain, LYT3 
T-cell surface glycoprotein CD8 beta chain (210 aa, ~24 kDa) is encoded by the human CD8B gene. This protein plays a role in T-cell cytotoxicity.
National Institutes of Health

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CD8 AntigensCD8A geneCD8B geneCD8B wt Allele
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Papers overview

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2015
2015
Transcriptomic correlates of organ failure extent in sepsis.
OBJECTIVES Sepsis is characterised by the frequent presence of organ failure and marked immunologic alterations. We studied the… (More)
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2015
2015
The DNA methylation signature of human TCRαβ+CD4-CD8- double negative T cells reveals CG demethylation and a unique epigenetic architecture permissive to a broad stimulatory immune response.
T cell receptor (TCR) αβ+CD4-CD8- double negative T cells represent a rare T cell subset implicated in the pathogenesis of… (More)
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2014
2014
Transcriptome analysis reveals an activation of major histocompatibility complex 1 and 2 pathways in chicken trachea immunized with infectious laryngotracheitis virus vaccine.
Infectious laryngotracheitis is an acute, contagious, upper respiratory disease of chickens caused by gallid herpes virus 1. Due… (More)
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2014
2014
CD8 subunit expression by plasmacytoid dendritic cells is variable, and does not define stable subsets
CD8 subunit expression by plasmacytoid dendritic cells is variable, and does not define stable subsets 
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Highly Cited
2006
Highly Cited
2006
Negative regulation of CD8 expression via Cd8 enhancer–mediated recruitment of the zinc finger protein MAZR
Coreceptor expression is tightly regulated during thymocyte development. Deletion of specific Cd8 enhancers leads to variegated… (More)
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2004
2004
Identification of key immune mediators regulating T helper 1 responses in swine.
This publication describes the cloning of full or partial length sequences for pig TBX21 (T-bet), MYD88, ICSBP1, CD8A (CD8alpha… (More)
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1994
1994
Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice
CD8 is a cell surface glycoprotein on major histocompatibility complex class I-restricted T cells. Thymocytes and most peripheral… (More)
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1986
1986
Efficacy of gamma and alpha interferon (IFN) in the treatment of hairy cell leukemia (HCL)
Hairy-cel l leukemia is a B-cel l tumor in which IFN-~has recent ly been shown to have a clear antitumor ef fect . In order to… (More)
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1983
1983
Evaluation of the circulating and splenic lymphocyte subpopulations in patients with non-hodgkin lymphomas and Hodgkin's disease using monoclonal antibodies
SummaryThe number of B lymphocytes, T lymphocytes and their helper/inducer, cytotoxic/suppressor and NK/K subpopulations was… (More)
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1983
1983
Phenotypes of human large granular lymphocytes as defined by monoclonal antibodies.
Four monoclonal antibodies VEP8, VEP9, VIM-D5, VIB-C5 against antigens expressed on human mature myeloid cells (polymorphonuclear… (More)
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