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CD59 protein, human

Known as: 20 kDa homologous restriction factor, human, MEM43 Antigen, CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) protein, human 
CD59 glycoprotein (128 aa, ~14 kDa) is encoded by the human CD59 gene. This protein is involved in the inhibition of the assembly of the membrane… 
National Institutes of Health

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Broader (1)

CD59 Antigen
CD59 geneCD59 wt AlleleGenes, RegulatorGlycoproteins

Papers overview

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2013
2013
Measurement of macular ganglion cell layer and circumpapillary retinal nerve fiber layer to detect paracentral scotoma in early glaucoma
BackgroundGlaucoma patients with paracentral scotoma are at higher risk of losing central vision than those without glaucoma. The… 
Highly Cited
2005
Highly Cited
2005
Transgenic pigs expressing human CD59, in combination with human membrane cofactor protein and human decay‐accelerating factor
Abstract:  Background:  The expression of human complement regulators has been proved as an effective strategy to overcome… 
Review
2003
Review
2003
Laboratory diagnosis of paroxysmal nocturnal hemoglobinuria.
Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon acquired stem cell disorder associated with periodic hemolytic events… 
Highly Cited
1998
Highly Cited
1998
Knock out of alpha1,3-galactosyltransferase or expression of alpha1,2-fucosyltransferase further protects CD55- and CD59-expressing mouse hearts in an ex vivo model of xenograft rejection.
BACKGROUND Organs from transgenic animals with high-level endothelial expression of the human complement regulatory factors CD55… 
1997
1997
Expression of CD59, a regulator of the membrane attack complex of complement, on human skeletal muscle fibers
Control of complement deposition on autologous cells is mediated by a group of complement regulatory membrane proteins acting at… 
Highly Cited
1994
Highly Cited
1994
Complement-inhibiting activities of human CD59 and analogues from rat, sheep, and pig are not homologously restricted.
Human erythrocyte CD59 and analogues isolated from erythrocytes of rat, sheep, and pig were examined for their ability to protect… 
Highly Cited
1994
Highly Cited
1994
High-density lipoproteins can act as carriers of glycophosphoinositol lipid-anchored CD59 in human plasma.
CD59 (protectin) is a glycophosphoinositol (GPI) lipid-anchored inhibitor of complement lysis that is expressed on the membranes… 
Review
1992
Review
1992
Membrane inhibitor of reactive lysis.
The membrane inhibitor of reactive lysis (MIRL, CD59) is an 18 kDa glycosyl phosphatidylinositol-anchored membrane glycoprotein… 
Highly Cited
1992
Highly Cited
1992
Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein… 
Highly Cited
1989
Highly Cited
1989
20 KDa homologous restriction factor of complement resembles T cell activating protein.
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