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Mortality in sickle cell disease. Life expectancy and risk factors for early death.
BACKGROUND Information on life expectancy and risk factors for early death among patients with sickle cell disease (sickle cell anemia, sickle cell-hemoglobin C disease, and the sickle… Expand
Pain in sickle cell disease. Rates and risk factors.
- O. Platt, B. D. Thorington, +4 authors T. Kinney
- The New England journal of medicine
- 4 July 1991
BACKGROUND AND METHODS Acute episodes of pain are the principal symptom of sickle cell disease, but little is known about the epidemiologic features of these episodes or risk factors for them, nor is… Expand
Diagnosis and management of paroxysmal nocturnal hemoglobinuria.
The primary clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH) are hemolytic anemia, marrow failure, and thrombophilia. However, PNH is not a simple binary diagnosis and both flow… Expand
Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry
- M. Borowitz, F. Craig, +5 authors S. Richards
- Cytometry. Part B, Clinical cytometry
- 1 July 2010
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematopoietic stem cell disorder characterized by a somatic mutation in the PIGA gene, leading to a deficiency of proteins linked to the cell… Expand
Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor.
Decay accelerating factor (DAF, CD55) is a glycophospholipid-anchored membrane protein that protects cells from complement-mediated damage by inhibiting the formation and accelerating the decay of… Expand
The natural history of paroxysmal nocturnal hemoglobinuria.
- W. Rosse
- Revista de investigacion clinica; organo del…
- 1 May 1997
The cooperative study of sickle cell disease: review of study design and objectives.
Although sickle cell disease has been known for years and many of its manifestations have been recognized, the "natural history" or clinical course of the disease from early childhood to death is not… Expand
Splenectomy for Primary and Recurrent Immune Thrombocytopenic Purpura (ITP): Current Criteria for Patient Selection and Results
Of 565 patients with thrombocytopenia admitted to Duke University Hospital between 1975 and 1985, 100 had splenectomy. Ninety-eight patients had failed chronic immunosuppressive therapy and three… Expand
The use of monoclonal antibodies and flow cytometry in the diagnosis of paroxysmal nocturnal hemoglobinuria.
We have characterized the erythrocytes, granulocytes, and platelets of 54 patients with paroxysmal nocturnal hemoglobinuria (PNH) with antibodies to glycosylphosphatidylinositol-anchored proteins… Expand