CC-885
National Institutes of Health
Papers overview
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Immunomodulatory drugs (IMiDs) are a new class of anticancer compounds that are derived from thalidomide. Lenalidomide and…
The protein cereblon is part of the CRL4-CRBN E3 ubiquitin ligase complex, and has been shown to be the molecular target for the…
A common motif likely promotes binding of substrates, including GSPT1, to cereblon.