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CC-885

National Institutes of Health

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3 relations

Broader (2)

Phenylurea CompoundsThalidomide
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L
Mitophagy is a degradative pathway that mediates the degradation of the entire mitochondria, and defects in this process are… 
2020
2020
A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer
2020
2020
Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide
Pomalidomide, a derivative of thalidomide, is an effective treatment for multiple myeloma. The drug exerts its effects through… 
Review
2019
Review
2019
Treatment of Lymphoid and Myeloid Malignancies by Immunomodulatory Drugs.
Thalidomide and its derivatives (lenalidomide, pomalidomide, avadomide, iberdomide hydrochoride, CC-885 and CC-90009) form the… 
2018
2018
Dynamic Imaging of Small Molecule Induced Protein-Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach.
Protein-protein interactions (PPIs) mediate signal transduction in cells. Small molecules that regulate PPIs are important tools… 
2017
2017
Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1.
We previously disclosed the identification of cereblon modulator 3 (CC-885), with potent antitumor activity mediated through the… 
Review
2017
Review
2017
Recent topics in IMiDs and cereblon.
Immunomodulatory drugs (IMiDs) are a new class of anticancer compounds that are derived from thalidomide. Lenalidomide and… 
2017
2017
Abstract SY37-02: Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects
The protein cereblon is part of the CRL4-CRBN E3 ubiquitin ligase complex, and has been shown to be the molecular target for the… 
2016
2016
The Cereblon Modulator CC-885 Exhibits Antitumor Activity.
A common motif likely promotes binding of substrates, including GSPT1, to cereblon. 
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