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CC-115

Known as: DNA-PK/TOR Kinase Inhibitor CC-115 
A dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract 5891: ABCG2 expression contributes to CC-115 resistance
  • Jenny Beebe
  • Experimental and Molecular Therapeutics
  • 2018
  • Corpus ID: 81458244
Introduction: A major obstacle in the treatment of cancers is innate or acquired resistance. Multi-drug resistance proteins such… 
2018
2018
c15-160: Enzalutamide (ENZA) plus CC-115 in men with metastatic castration-resistant prostate cancer (mCRPC): A phase 1b Prostate Cancer Clinical Trials Consortium study.
5045Background: Studies in PTEN-deficient prostate cancer (PC) models have shown additive anti-tumor activity when ENZA is… 
2017
2017
Abstract LB-264: Preclinical evaluation of DNA-PK as a therapeutic target in prostate cancer
Prostatic adenocarcinoma (PCa) is dependent on androgen receptor (AR) signaling at all stages of disease, as AR activation… 
2016
2016
Phase I trial of a dual TOR kinase and DNA-PK inhibitor (CC-115) in advanced solid and hematologic cancers.
2505Background: CC-115 is a potent inhibitor of DNA-PK and TOR kinase (DNA-PKi/TORKi) with broad pre-clinical anti-tumor activity… 
Review
2016
Review
2016
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Mar; 160(1)
Background. DNA repair pathways play a major role in tumour resistance towards chemoand radiotherapy. Therefore, inhibitors of… 
2015
2015
Abstract 1755: TORK/DNA-PK inhibitor CC-115 is effective as a single agent in a subset of glioblastoma patient-derived cancer stem cells and xenografts and potentiates temozolomide therapy
Glioblastoma (GBM) cells are highly invasive and respond poorly to radiation and chemotherapy. The mammalian target of rapamycin… 
2014
2014
459 Preclinical characterization of CC-115, a novel inhibitor of DNA-PK and mTOR kinase currently under clinical investigation
2014
2014
306 CC-115 inhibits DNA damage and repair pathways in vitro
2014
2014
523 Antitumor activity of mTOR kinase and DNA-PK inhibitor CC-115 in a mouse model of glioblastoma
1972
1972
Static and Drop Tests of a Quarter Scale Model of the CC-115 Aircraft Equipped with an Air Cushion Landing System
Abstract : Static load deflection tests and vertical drop tests were performed on a quarter scale model of a Canadian CC-115… 
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