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CBR 703

Known as: CBR-703, CBR703 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

AmidinesHydroxylamines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.
CBR hydroxamidines are small-molecule inhibitors of bacterial RNA polymerase (RNAP) discovered through high-throughput screening… Expand
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2014
2014
CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase
Bacterial RNA polymerase (RNAP) is a validated target for antibacterial drugs. CBR703 series antimicrobials allosterically… Expand
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2014
2014
New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.
CBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for… Expand
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2007
2007
In vitro activities of different inhibitors of bacterial transcription against Staphylococcus epidermidis biofilm.
Staphylococcus epidermidis is a major cause of nosocomial infections because of its ability to form biofilms on the surface of… Expand
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2003
2003
A new class of bacterial RNA polymerase inhibitor affects nucleotide addition.
RNA polymerase (RNAP) is the central enzyme of gene expression. Despite availability of crystal structures, details of its… Expand
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