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CAN 508

Known as: CAN-508, CAN508 
 
National Institutes of Health

Papers overview

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2020
2020
In the present study, we report the design and synthesis of novel CAN508 sulfonamide-based analogues (4, 8a-e, 9a-h and 10a-e) as… Expand
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2019
2019
Two new series of pyrrolizine-5-carboxamides were synthesized and evaluated for their anticancer and anti-inflammatory activities… Expand
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2018
2018
Cyclin-dependent kinases (CDKs) are promising drug targets for various human diseases, especially for cancers. Scaffold hopping… Expand
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2018
2018
The cyclin-dependent kinase inhibitor, CAN508, was protected with di-tert-butyl dicarbonate to access the amino-benzoylated… Expand
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2017
2017
A general and efficient synthesis of 4-substituted-1H-pyrazole-3,5-diamines was developed to access derivatives with an aryl… Expand
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2017
2017
Role of cyclin dependent kinase 9(CDK9) as a potential target in esophageal adenocarcinoma (EAC) is unknown. We investigated CDK9… Expand
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2015
2015
Here, we describe new 4-arylazo-3,5-diamino-1H-pyrazole derivatives developed from CAN508, one of the first inhibitors to show… Expand
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2012
2012
CDK9 is the kinase of positive transcription elongation factor b and facilitates the transition of paused RNA polymerase II to… Expand
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2011
2011
Small molecule inhibitors of cyclin-dependent kinases (CDK) have been developed as anticancer drugs with cytostatic and cytotoxic… Expand
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Highly Cited
2006
Highly Cited
2006
In a routine screening of our small-molecule compound collection we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a… Expand
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