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CAN 508

Known as: CAN-508, CAN508 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Azo CompoundsPyrazoles

Papers overview

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2019
2019
Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency.
2018
2018
Discovery of novel CDK inhibitors via scaffold hopping from CAN508.
2018
2018
Modification of Boc-Protected CAN508 via Acylation and Suzuki-Miyaura Coupling
The cyclin-dependent kinase inhibitor, CAN508, was protected with di-tert-butyl dicarbonate to access the amino-benzoylated… 
2017
2017
Synthesis of 4-substituted pyrazole-3,5-diamines via Suzuki-Miyaura coupling and iron-catalyzed reduction.
A general and efficient synthesis of 4-substituted-1H-pyrazole-3,5-diamines was developed to access derivatives with an aryl… 
2017
2017
Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma
Role of cyclin dependent kinase 9(CDK9) as a potential target in esophageal adenocarcinoma (EAC) is unknown. We investigated CDK9… 
2015
2015
Novel arylazopyrazole inhibitors of cyclin-dependent kinases.
2011
2011
The selective P-TEFb inhibitor CAN508 targets angiogenesis.
Highly Cited
2006
Highly Cited
2006
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
In a routine screening of our small-molecule compound collection we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a… 
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