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Myocardial injury induced by diabetes has become an increasing health problem. Chrysophanol (CHR) has been widely studied as a… Expand Arachidonic acid can be metabolized by cytochrome P450 (CYP450) enzymes in a tissue- and cell-specific manner to generate… Expand Wide variation exists in the extent (number and diameter) of native pre-existing collaterals in tissues of different strains of… Expand Countering the diabetes pandemic and consequent complications, such as nephropathy, will require better understanding of disease… Expand An obesity‐induced diabetes model using genetically normal mouse strains would be invaluable but remains to be established. One… Expand OBJECTIVE—Glomerular mesangial expansion and podocyte loss are important early features of diabetic nephropathy, whereas… Expand C57BLKS db/db (db/db) mice develop a neuropathy with features of human type 2 diabetic neuropathy. Here, we demonstrate that… Expand Epidemiological evidence indicates a link between obesity and human colon cancer. A putative association between obesity and… Expand The fat gene in mice represents a recessive mutation at the carboxypeptidase E (Cpe) locus. The mutant allele (Cpefat) encodes a… Expand Functionally significant polymorphisms in endothelial nitric oxide synthase (eNOS) and reduced vascular eNOS activity have been… Expand