Physiologic and endocrinologic characterization of male sex-biased diabetes in C57BLKS/J mice congenic for the fat mutation at the carboxypeptidease E locus

@article{Leiter1999PhysiologicAE,
  title={Physiologic and endocrinologic characterization of male sex-biased diabetes in C57BLKS/J mice congenic for the fat mutation at the carboxypeptidease E locus},
  author={Dr. Edward H. Leiter and Jennifer Kintner and Kevin Flurkey and Wesley G. Beamer and J{\"u}rgen K Naggert},
  journal={Endocrine},
  year={1999},
  volume={10},
  pages={57-66}
}
The fat gene in mice represents a recessive mutation at the carboxypeptidase E (Cpe) locus. The mutant allele (Cpe fat ) encodes a highly unstable enzyme and produces an obesity phenotype characterized by attenuated processing of prohormones such as proinsulin that require this exopeptidase for full maturation. This article presents a preliminary physiologic and endocrinologic characterization of the stock of C57BLKS/LtJ-Cpe fat /Cpe fat mice at the backcross generation (N10) currently… CONTINUE READING