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C1R gene

Known as: C1R, complement C1r subcomponent, COMPLEMENT COMPONENT 1, r SUBCOMPONENT 
 
National Institutes of Health

Papers overview

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2018
2018
Significance C1 is a large complex that triggers the destruction of invading pathogens via lysis or by stimulation of innate and… Expand
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2015
2015
BackgroundEpigenetic aberrations play a central role in the pathophysiology of acute myeloid leukemia (AML). It has been shown… Expand
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Review
2014
Review
2014
The classical complement pathway is initiated by the large (~800 kDa) and flexible multimeric C1 complex. Its catalytic function… Expand
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2013
2013
Background: Classical complement pathway activation depends on cleavage of inactive C1s by C1r. Results: P2 Gln and P1′ Ile… Expand
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2008
2008
C1r is a modular serine protease which is the autoactivating component of the C1 complex of the classical pathway of the… Expand
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2005
2005
The availability of the human genome sequence allowed us to identify a human complement-related, C1r-like protease gene (c1r-LP… Expand
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1995
1995
 
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1978
1978
The first complement component, C1, was activated in normal human sera by addition of aggregated IgG, immune complexes, and… Expand
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1976
1976
C1r was unable to cleave and activate proenzyme C1s unless first incubated at 37 degrees C in the absence of calcium before the… Expand
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1976
1976
C1r was isolated from serum by an improved method and found to be a glycoprotein with a sedimentation coefficient of 7.0S. Under… Expand
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