Semantic Scholar uses AI to extract papers important to this topic.
Significance C1 is a large complex that triggers the destruction of invading pathogens via lysis or by stimulation of innate and… Expand BackgroundEpigenetic aberrations play a central role in the pathophysiology of acute myeloid leukemia (AML). It has been shown… Expand The classical complement pathway is initiated by the large (~800 kDa) and flexible multimeric C1 complex. Its catalytic function… Expand Background: Classical complement pathway activation depends on cleavage of inactive C1s by C1r. Results: P2 Gln and P1′ Ile… Expand C1r is a modular serine protease which is the autoactivating component of the C1 complex of the classical pathway of the… Expand The availability of the human genome sequence allowed us to identify a human complement-related, C1r-like protease gene (c1r-LP… Expand The first complement component, C1, was activated in normal human sera by addition of aggregated IgG, immune complexes, and… Expand C1r was unable to cleave and activate proenzyme C1s unless first incubated at 37 degrees C in the absence of calcium before the… Expand C1r was isolated from serum by an improved method and found to be a glycoprotein with a sedimentation coefficient of 7.0S. Under… Expand