Bradykinin B2 Receptor Antagonists

Blockade of the bradykinin B(2) receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many… Expand

Pharmacological studies using bradykinin B2 receptor antagonists suggest that bradykinin, an early mediator of inflammation and… Expand

The 1-(2-nitrophenyl)thiosemicarbazide (TSC) derivative, (S)-1-[4-(4-benzhydrylthiosemicarbazido)-3-nitrobenzenesulfonyl… Expand

The Bradykinin B2 receptor antagonist HOE 140 (D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg) has been used as a template for the… Expand

Orally active nonpeptide bradykinin (BK) B2 receptor antagonists have been discovered by using directed random screening and… Expand

1. Subcutaneous injection of sodium deoxycholic acid into the anterior of the back of male ddY mice elicited dose-dependent… Expand

A novel class of potent, selective, and orally active non-peptide bradykinin (BK) B2 receptor antagonists were designed and… Expand

1. Hoe 140, a recently described bradykinin B2 antagonist, and NPC 567 from an earlier generation of bradykinin B2 antagonists… Expand

1. The effects of bradykinin on nociceptors have been characterized on a preparation of the neonatal rat spinal cord with… Expand

AbstractpA2 values of new B2 receptor antagonists ranging from 7.51 to 8.86 were measured on the rabbit jugular vein, while lower… Expand