FAQ

Bradykinin B2 Receptor Antagonists

Known as: Bradykinin B2 Antagonists, Antagonists, Bradykinin B2, Bradykinin B2 Receptor Inhibitors 
Compounds and drugs that inhibit ligand binding or cellular signaling by BRADYKININ B2 RECEPTORS.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2018
02419912018

Related topics

Related topics

5 relations
In Bloodchemical synthesisisolation & purification analysisstandards characteristics

Narrower (1)

icatibant

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Bradykinin B2 Receptor Antagonists
In Blood
chemical synthesis
icatibant
standards characteristics
isolation & purification analysis

Papers overview

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2016
2016
New insights into the stereochemical requirements of the bradykinin B2 receptor antagonists binding
Bradykinin (BK) is a member of the kinin family, released in response to inflammation, trauma, burns, shock, allergy and some… (More)
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2012
2012
From bradykinin B2 receptor antagonists to orally active and selective bradykinin B1 receptor antagonists.
The bradykinin (BK) B1 receptor is an attractive target for the treatment of chronic pain and inflammation. Starting from a dual… (More)
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2009
2009
Novel small molecule bradykinin B2 receptor antagonists.
Blockade of the bradykinin B(2) receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many… (More)
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2002
2002
Nonpeptide bradykinin B2 receptor antagonists: conversion of rodent-selective bradyzide analogues into potent, orally-active human bradykinin B2 receptor antagonists.
The 1-(2-nitrophenyl)thiosemicarbazide (TSC) derivative, (S)-1-[4-(4-benzhydrylthiosemicarbazido)-3-nitrobenzenesulfonyl… (More)
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1999
1999
The design of non-peptide human bradykinin B2 receptor antagonists employing the benzodiazepine peptidomimetic scaffold.
The Bradykinin B2 receptor antagonist HOE 140 (D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg) has been used as a template for the… (More)
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Review
1999
Review
1999
Discovery of orally active nonpeptide bradykinin B2 receptor antagonists.
Orally active nonpeptide bradykinin (BK) B2 receptor antagonists have been discovered by using directed random screening and… (More)
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1998
1998
Activity of tachykinin NK1 and bradykinin B2 receptor antagonists, and an opioid ligand at different stimulation parameters in neurogenic inflammation in the rat.
Stimulation of the saphenous nerve in the anaesthetised rat results in cutaneous neurogenic oedema formation. We have examined… (More)
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1994
1994
Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species.
1. Hoe 140, a recently described bradykinin B2 antagonist, and NPC 567 from an earlier generation of bradykinin B2 antagonists… (More)
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1992
1992
Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro.
1. The effects of bradykinin on nociceptors have been characterized on a preparation of the neonatal rat spinal cord with… (More)
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1991
1991
New highly potent bradykinin B2 receptor antagonists
pA2 values of new B2 receptor antagonists ranging from 7.51 to 8.86 were measured on the rabbit jugular vein, while lower values… (More)
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