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- Publications
- Influence
EDHF: bringing the concepts together.
- R. Busse, G. Edwards, M. Félétou, I. Fleming, P. Vanhoutte, A. Weston
- Medicine, Chemistry
- Trends in pharmacological sciences
- 1 August 2002
Endothelial cells synthesize and release vasoactive mediators in response to various neurohumoural substances (e.g. bradykinin or acetylcholine) and physical stimuli (e.g. cyclic stretch or fluid… Expand
Acetylcholine‐induced endothelium‐dependent contractions in the SHR aorta: the Janus face of prostacyclin
- P. Gluais, M. Lonchampt, J. Morrow, P. Vanhoutte, M. Félétou
- Medicine, Chemistry
- British journal of pharmacology
- 1 November 2005
In the spontaneously hypertensive rat (SHR) and aging Wistar–Kyoto rats (WKY), acetylcholine releases an endothelium‐derived contracting factor (EDCF) produced by endothelial cyclooxygenase‐1, which… Expand
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture).
- M. Félétou, P. Vanhoutte
- Medicine
- American journal of physiology. Heart and…
- 1 September 2006
Endothelial cells synthesize and release various factors that regulate angiogenesis, inflammatory responses, hemostasis, as well as vascular tone and permeability. Endothelial dysfunction has been… Expand
Endothelium-derived hyperpolarising factors and associated pathways: a synopsis
- G. Edwards, M. Félétou, A. Weston
- Chemistry, Medicine
- Pflügers Archiv - European Journal of Physiology
- 11 April 2010
The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to describe the hypothetical factor responsible for myocyte hyperpolarisations not associated with nitric oxide… Expand
Endothelial dysfunction and vascular disease
- P. Vanhoutte, H. Shimokawa, E. H. Tang, M. Félétou
- Medicine
- Acta physiologica
- 1 June 2009
The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium‐derived relaxing factor (EDRF) is… Expand
Endothelium-Derived Hyperpolarizing Factor: Where Are We Now?
- M. Félétou, P. Vanhoutte
- Medicine, Chemistry
- Arteriosclerosis, thrombosis, and vascular…
- 1 June 2006
The endothelium controls vascular tone not only by releasing nitric oxide (NO) and prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth muscle cells. This… Expand
EDHF: an update.
- M. Félétou, P. Vanhoutte
- Biology, Medicine
- Clinical science
- 1 August 2009
The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also by other pathways causing hyperpolarization of the underlying smooth muscle cells. This characteristic was… Expand
Endothelium‐mediated control of vascular tone: COX‐1 and COX‐2 products
- M. Félétou, Y. Huang, P. Vanhoutte
- Medicine
- British journal of pharmacology
- 1 October 2011
Endothelium‐dependent contractions contribute to endothelial dysfunction in various animal models of aging, diabetes and cardiovascular diseases. In the spontaneously hypertensive rat, the archetypal… Expand
Endothelium‐dependent contractions in hypertension
- P. Vanhoutte, M. Félétou, S. Taddei
- Medicine, Chemistry
- British journal of pharmacology
- 1 February 2005
1 Endothelial cells, under given circumstances, can initiate contraction (constriction) of the vascular smooth muscle cells that surround them. Such endothelium‐dependent, acute increases in… Expand
Endothelium‐dependent hyperpolarization of canine coronary smooth muscle
- M. Félétou, P. Vanhoutte
- Chemistry, Medicine
- British journal of pharmacology
- 1 March 1988
1 Experiments were designed to determine whether endothelium‐dependent relaxing factor(s) released by acetylcholine from the canine femoral artery influences the membrane potential of coronary… Expand