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Blastodisc

Known as: Areas, Germinal, Germinal Area, Germinal Discs 
A small whitish spot on the surface of the EGG YOLK where cleavage begins. Upon fertilization the cytoplasm streams from the vegetal pole away from… 
National Institutes of Health

Related topics

Related topics

5 relations
Blood supply aspectsMicrobiologicalProcess of secretionaspects of radiation effects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
T cells and follicular dendritic cells in germinal center B‐cell formation and selection
Summary:  Germinal centers (GCs) are specialized microenvironments formed after infection where activated B cells can mutate… 
Highly Cited
2003
Highly Cited
2003
In Situ Studies of the Primary Immune Response to ( 4-hydroxy-3-nitrophenyl ) acetyl . II . A Common Clonal Origin for Periarteriolar Lymphoid Sheath-associated Foci and Germinal Centers
In the genetically restricted response that follows immunization with (4-hydroxy-3-nitrophenyl)acetyl coupled to protein carriers… 
Highly Cited
2000
Highly Cited
2000
Germinal Centers without T Cells
Germinal centers are critical for affinity maturation of antibody (Ab) responses. This process allows the production of high… 
Highly Cited
1997
Highly Cited
1997
V(D)J recombination in mature B cells: a mechanism for altering antibody responses.
The clonal selection theory states that B lymphocytes producing high-affinity immunoglobulins are selected from a pool of cells… 
Review
1992
Review
1992
Maturation and Dispersal of B‐Cell Clones during T Cell‐Dependent Antibody Responses
Germinal centers develop in follicles during TD antibody responses in the first 3 wk following each immunization. In primary… 
Highly Cited
1992
Highly Cited
1992
Meiosis, egg activation, and nuclear envelope breakdown are differentially reliant on Ca2+, whereas germinal vesicle breakdown is Ca2+ independent in the mouse oocyte
During early development, intracellular Ca2+ mobilization is not only essential for fertilization, but has also been implicated… 
Highly Cited
1992
Highly Cited
1992
What limits affinity maturation of antibodies in Xenopus‐‐the rate of somatic mutation or the ability to select mutants?
Although the Xenopus immunoglobulin heavy chain locus is structurally and functionally similar to mammalian IgH loci, Xenopus… 
Highly Cited
1991
Highly Cited
1991
Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis
B cells undergo selection within germinal centers on the basis of their capacity to be activated by antigen held on follicular… 
Highly Cited
1987
Highly Cited
1987
Vasculogenesis in the early quail blastodisc as studied with a monoclonal antibody recognizing endothelial cells.
QH1, a monoclonal antibody that recognizes quail endothelial and haemopoietic cells, was applied to quail blastodiscs in toto, in… 
Highly Cited
1983
Highly Cited
1983
Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.
We isolated germinal center B cells by exploiting their high affinity for peanut agglutinin (PNA). The PNA+ and PNA- B cells… 
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