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Biospecimen Core Resource Facility
Known as:
BCR
, Biospecimen Core Resource
A central facility to qualify, quality assure, and distribute human biomolecules in support of the development of the Cancer Genome Atlas (TCGA…
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National Institutes of Health
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Papers overview
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Highly Cited
2008
Highly Cited
2008
Suppression of Programmed Cell Death 4 (PDCD4) Protein Expression by BCR-ABL-regulated Engagement of the mTOR/p70 S6 Kinase Pathway*
N. Carayol
,
Efstratios Katsoulidis
,
A. Sassano
,
J. Altman
,
B. Druker
,
L. Platanias
Journal of Biological Chemistry
2008
Corpus ID: 23075808
There is accumulating evidence that mammalian target of rapamycin (mTOR)-activated pathways play important roles in cell growth…
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2005
2005
The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines.
Yaoxian Xu
,
S. Voelter-Mahlknecht
,
U. Mahlknecht
International Journal of Molecular Medicine
2005
Corpus ID: 19449405
In chronic myelocytic leukemia (CML) the activity of the Bcr-Abl tyrosine kinase is known to activate a number of molecular…
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2003
2003
Bcr‐Abl upregulates cytosolic p21WAF‐1/CIP‐1 by a phosphoinositide‐3‐kinase (PI3K)‐independent pathway
Karen Keeshan
,
T. Cotter
,
S. McKenna
British Journal of Haematology
2003
Corpus ID: 32448869
Summary. Chronic myeloid leukaemia invariably progresses from a drug‐sensitive to a drug‐resistant, aggressive acute leukaemia…
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Review
2001
Review
2001
New views of BCR structure and organization.
L. Matsuuchi
,
M. Gold
Current Opinion in Immunology
2001
Corpus ID: 40613378
Highly Cited
1997
Highly Cited
1997
Bcr phosphorylated on tyrosine 177 binds Grb2
G. Ma
,
D. Lu
,
Yun Wu
,
Jiaxin Liu
,
R. Arlinghaus
Oncogene
1997
Corpus ID: 9249479
We and others have shown that the Bcr-Abl oncoprotein binds activators of the Ras pathway such as Grb2 and Shc. Grb2 binding is…
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1996
1996
Kinetic selectivity of complementary nucleic acids: bcr-abl-directed antisense RNA and ribozymes.
Ralf Kronenwett
,
Rainer Haas
,
George Sczakiel
Journal of Molecular Biology
1996
Corpus ID: 2209730
Efficacy and sequence specificity are two major requirements in the use of antisense nucleic acids and ribozymes. For long-chain…
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Highly Cited
1994
Highly Cited
1994
Tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in K562 chronic myelogenous leukemia.
Gurmeet Kaur
,
A. Gazit
,
Alexander Levitzki
,
Emily Stowe
,
David A. Cooney
,
E A Sausville
Anti-Cancer Drugs
1994
Corpus ID: 19639573
We have examined a series of tyrosine kinase inhibitors structurally related to erbstatin (tyrphostins) for inhibition of p210bcr…
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1993
1993
Frequent detection of BCR-ABL specific mRNA in patients with chronic myeloid leukemia (CML) following allogeneic and syngeneic bone marrow transplantation (BMT).
Alexander Gaiger
,
Thomas Lion
,
+7 authors
P. Quehenberger
Leukemia
1993
Corpus ID: 19418615
We performed a two-step polymerase chain reaction (PCR) to detect bcr-abl-specific mRNA in 440 peripheral blood and/or bone…
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Review
1988
Review
1988
Molecular biology of chronic myelogenous leukemia.
O. Dreazen
,
E. Canaani
,
R. Gale
Seminars in hematology (Print)
1988
Corpus ID: 31045097
In this review we have described molecular consequences of the t(9;22) translocation typical of CML and some cases of ALL. This…
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Highly Cited
1986
Highly Cited
1986
bcr rearrangement in Ph-negative CML.
C. Bartram
,
F. Carbonell
Cancer Genetics and Cytogenetics
1986
Corpus ID: 33364198
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