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Biospecimen Core Resource Facility

Known as: BCR, Biospecimen Core Resource 
A central facility to qualify, quality assure, and distribute human biomolecules in support of the development of the Cancer Genome Atlas (TCGA… 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Suppression of Programmed Cell Death 4 (PDCD4) Protein Expression by BCR-ABL-regulated Engagement of the mTOR/p70 S6 Kinase Pathway*
There is accumulating evidence that mammalian target of rapamycin (mTOR)-activated pathways play important roles in cell growth… 
2005
2005
The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines.
In chronic myelocytic leukemia (CML) the activity of the Bcr-Abl tyrosine kinase is known to activate a number of molecular… 
2003
2003
Bcr‐Abl upregulates cytosolic p21WAF‐1/CIP‐1 by a phosphoinositide‐3‐kinase (PI3K)‐independent pathway
Summary. Chronic myeloid leukaemia invariably progresses from a drug‐sensitive to a drug‐resistant, aggressive acute leukaemia… 
Review
2001
Review
2001
New views of BCR structure and organization.
Highly Cited
1997
Highly Cited
1997
Bcr phosphorylated on tyrosine 177 binds Grb2
We and others have shown that the Bcr-Abl oncoprotein binds activators of the Ras pathway such as Grb2 and Shc. Grb2 binding is… 
1996
1996
Kinetic selectivity of complementary nucleic acids: bcr-abl-directed antisense RNA and ribozymes.
Efficacy and sequence specificity are two major requirements in the use of antisense nucleic acids and ribozymes. For long-chain… 
Highly Cited
1994
Highly Cited
1994
Tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in K562 chronic myelogenous leukemia.
We have examined a series of tyrosine kinase inhibitors structurally related to erbstatin (tyrphostins) for inhibition of p210bcr… 
1993
1993
Frequent detection of BCR-ABL specific mRNA in patients with chronic myeloid leukemia (CML) following allogeneic and syngeneic bone marrow transplantation (BMT).
We performed a two-step polymerase chain reaction (PCR) to detect bcr-abl-specific mRNA in 440 peripheral blood and/or bone… 
Review
1988
Review
1988
Molecular biology of chronic myelogenous leukemia.
In this review we have described molecular consequences of the t(9;22) translocation typical of CML and some cases of ALL. This… 
Highly Cited
1986
Highly Cited
1986
bcr rearrangement in Ph-negative CML.
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