Bilaminar embryonic disc

Known as: Bilaminar disk, Embryo proper, Bilaminar blastoderm 
An embryonic structure that appears as a disc composed of epiblast and hypoblast sac.
National Institutes of Health

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EmbryoEpiblastHypoblastInner cell mass
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Papers overview

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Highly Cited
2009
Highly Cited
2009
Nanog Is the Gateway to the Pluripotent Ground State
Pluripotency is generated naturally during mammalian development through formation of the epiblast, founder tissue of the embryo… (More)
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Highly Cited
2004
Highly Cited
2004
Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells.
A very small number of embryonic stem (ES) cells gives rise to all tissues of the embryo proper. This means that ES cells should… (More)
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Highly Cited
2000
Highly Cited
2000
The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling.
We have studied the role of the basic helix-loop-helix-PAS transcription factor EPAS-1/hypoxia-inducible factor 2alpha in… (More)
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Highly Cited
2000
Highly Cited
2000
Eomesodermin is required for mouse trophoblast development and mesoderm formation
The earliest cell fate decision in the mammalian embryo separates the extra-embryonic trophoblast lineage, which forms the fetal… (More)
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Highly Cited
2000
Highly Cited
2000
Vasculogenesis in the day 6.5 to 9.5 mouse embryo.
The process of vasculogenesis was characterized in the 6.5- to 9.5-day mouse embryo and in allantoic culture by analysis of… (More)
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Highly Cited
1999
Highly Cited
1999
Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.
In this study, we have mapped the onset of hematopoietic development in the mouse embryo using colony-forming progenitor assays… (More)
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Highly Cited
1998
Highly Cited
1998
In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos.
We have investigated the lymphohematopoietic potentials of endothelial cells (EC) and hematopoietic cells (HPC) sorted from… (More)
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Highly Cited
1997
Highly Cited
1997
Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL.
The TEL gene, which is frequently rearranged in human leukemias of both myeloid and lymphoid origin, encodes a member of the Ets… (More)
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Highly Cited
1993
Highly Cited
1993
Role of insulin-like growth factors in embryonic and postnatal growth
A developmental analysis of growth kinetics in mouse embryos carrying null mutations of the genes encoding insulin-like growth… (More)
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Highly Cited
1989
Highly Cited
1989
Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study.
In mouse embryos, acquisition of the nuclear lamin polypeptides A/C varies according to developmental stage and tissue type. In… (More)
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