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Beta-1,4 N-Acetylgalactosaminyltransferase 1, Human

Known as: GD2 Synthase, GM2 Synthase, GD2 Synthase, GalNAc-T 
Beta-1,4 N-acetylgalactosaminyltransferase 1 (533 aa, ~59 kDa) is encoded by the human B4GALNT1 gene. This protein is involved in ganglioside… 
National Institutes of Health

Related topics

Related topics

11 relations
(N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferaseB4GALNT1 geneB4GALNT1 wt AlleleCarbohydrate Metabolism

Papers overview

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2018
2018
Characterization of a Mucopolysaccharidosis Type I and GalNAc Transferase deficiency double knockout mouse
The mucopolysaccharidoses (MPSs) are a group of lysosomal storage diseases (LSDs) which are characterized by the aberrant primary… 
2008
2008
Increased levels of xylosyltransferase I correlate with the mineralization of the extracellular matrix during osteogenic differentiation of mesenchymal stem cells.
2006
2006
The wbnH gene of Escherichia coli O86:H2 encodes an alpha-1,3-N-acetylgalactosaminyl transferase involved in the O-repeating unit biosynthesis.
2006
2006
Complex Formation of Glycosyltransferases and Their Biological Significance
近年糖転移酵素が種々の様式で複合体を形成することが判ってきた。ある種の糖転移酵素はホモダイマーやホモオリゴマーを形成し、またあるものは糖転移酵素以外のタンパク質と会合し、ヘテロオリゴマーを形成する。糖転移酵素が複合体を形成する生物学的意義として、酵素の触媒機能の安定化や活性化、基質特異性の変化、効率的な糖鎖の合成、細胞内オルガネラにおける局在性や輸送、他のエフェクタータンパク質による触媒機能の調節、などが挙げられる。このように糖転移酵素の複合体は機能的・構造的に多種多様であるが、本稿ではこれら種々の研究例について概観する。 
2000
2000
CHANGES IN LIVER GANGLIOSIDES IN STREPTOZOTOCIN‐INDUCED DIABETIC RATS
Diabetes mellitus is associated with various structural and functional liver abnormalities that affect the glycogen and lipid… 
1998
1998
Two soluble glycosyltransferases glycosylate less efficiently in vivo than their membrane bound counterparts.
Many Golgi glycosyltransferases are type II membrane proteins which are cleaved to produce soluble forms that are released from… 
1997
1997
Beta 1,4 N-acetylgalactosaminyltransferase (GM2/GD2/GA2 synthase) forms homodimers in the endoplasmic reticulum: a strategy to test for dimerization of Golgi membrane proteins.
Many Golgi membrane-bound glycosyltransferases exist as intermolecular disulfide bonded species, some of which have been… 
1997
1997
Appearance of beta 1,4 N-acetylgalactosaminyltransferase (glycosphingolipids GA2/GM2/GD2 synthase) in embryonic chicken vitreous humor during development.
PURPOSE beta 1,4 N-Acetylgalactosaminyltransferase (GalNAcT) is a type II integral membrane protein of the Golgi apparatus that… 
1996
1996
β1,4-N-Acetylgalactosaminyltransferase (GM2 Synthase) Is Released from Golgi Membranes as a Neuraminidase-sensitive, Disulfide-bonded Dimer by a Cathepsin D-like Protease*
Many Golgi membrane-bound glycosyltransferases are released from cells in a soluble form. To characterize this release process… 
1996
1996
Cloned β1,4N-acetylgalactosaminyltransferase: subcellular localization and formation of disulfide bonded species
Cloned human β1,4N-acetylgalactosaminyltransferase (GalNAcT) catalyses the synthesis of the glycosphingolipids GM2, GD2, and… 
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