FAQ

Beta-1,4 N-Acetylgalactosaminyltransferase 1, Human

Known as: GD2 Synthase, GM2 Synthase, GD2 Synthase, GalNAc-T 
Beta-1,4 N-acetylgalactosaminyltransferase 1 (533 aa, ~59 kDa) is encoded by the human B4GALNT1 gene. This protein is involved in ganglioside… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2012
02419842012

Related topics

Related topics

12 relations
(N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferaseB4GALNT1 geneB4GALNT1 wt AlleleCarbohydrate Metabolism
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Beta-1,4 N-Acetylgalactosaminyltransferase 1, Human
Lipid Metabolism
Carbohydrate Metabolism
Integral Membrane Proteins
Transmembrane Domain
glycosylation

Papers overview

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2006
2006
Cytoplasmic tails of SialT2 and GalNAcT impose their respective proximal and distal Golgi localization.
Complex glycolipid synthesis is catalyzed by different glycosyltransferases resident of the Golgi complex. Most of them are type… (More)
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2006
2006
The wbnH gene of Escherichia coli O86:H2 encodes an alpha-1,3-N-acetylgalactosaminyl transferase involved in the O-repeating unit biosynthesis.
O-repeating unit biosynthesis is the first committed step in lipopolysaccharide (LPS) biosynthesis in a variety of gram-negative… (More)
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2005
2005
Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1.
Knock-out (KO) mice lacking gangliotetraose gangliosides attributable to disruption of the gene for GM2/GD2 synthase [GalNAcT… (More)
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2005
2005
Novel poly-GalNAcbeta1-4GlcNAc (LacdiNAc) and fucosylated poly-LacdiNAc N-glycans from mammalian cells expressing beta1,4-N-acetylgalactosaminyltransferase and alpha1,3-fucosyltransferase.
Glycans containing the GalNAcbeta1-4GlcNAc (LacdiNAc or LDN) motif are expressed by many invertebrates, but this motif also… (More)
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2003
2003
Quantitation of GD2 synthase mRNA by real-time reverse transcriptase polymerase chain reaction: clinical utility in evaluating adjuvant therapy in neuroblastoma.
PURPOSE Minimal residual disease (MRD) is one of the final hurdles to cancer cure. Because therapy (myeloablation, immunotherapy… (More)
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2002
2002
Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases.
Three key regulatory enzymes in ganglioside biosynthesis, sialyltransferase I (ST1), sialyltransferase II (ST2), and N… (More)
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Highly Cited
1999
Highly Cited
1999
Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects.
Gangliosides are a family of sialic acid-containing glycosphingolipids highly enriched in the mammalian nervous system. Although… (More)
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1995
1995
The effects of the site-directed removal of N-glycosylation sites from beta-1,4-N-acetylgalactosaminyltransferase on its function.
The amino acid sequence deduced from the cloned human cDNA of beta-1,4-N-acetylgalactosaminyltransferase (GalNAc-T; EC 2.4.1.92… (More)
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1995
1995
Regulation of glycolipid synthesis in HL-60 cells by antisense oligodeoxynucleotides to glycosyltransferase sequences: effect on cellular differentiation.
Treatment of the human promyelocytic leukemia cell line HL-60 with antisense oligodeoxynucleotides to UDP-N-acetylgalactosamine… (More)
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1992
1992
Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides.
GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids expressed in some normal tissues such as brain and in… (More)
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