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Beta-1,4 N-Acetylgalactosaminyltransferase 1, Human

Known as: GD2 Synthase, GM2 Synthase, GD2 Synthase, GalNAc-T 
Beta-1,4 N-acetylgalactosaminyltransferase 1 (533 aa, ~59 kDa) is encoded by the human B4GALNT1 gene. This protein is involved in ganglioside… 
National Institutes of Health

Related topics

Related topics

11 relations
(N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferaseB4GALNT1 geneB4GALNT1 wt AlleleCarbohydrate Metabolism

Papers overview

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2014
2014
Neuronal Expression of GalNAc Transferase Is Sufficient to Prevent the Age-Related Neurodegenerative Phenotype of Complex Ganglioside-Deficient Mice
Gangliosides are widely expressed sialylated glycosphingolipids with multifunctional properties in different cell types and… 
2012
2012
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity.
Glycosaminoglycan (GAG) assembly initiates through the formation of a linkage tetrasaccharide region serving as a primer for both… 
2008
2008
Increased levels of xylosyltransferase I correlate with the mineralization of the extracellular matrix during osteogenic differentiation of mesenchymal stem cells.
2008
2008
Calsenilin and CALP interact with the cytoplasmic tail of UDP-Gal:GA2/GM2/GD2 beta-1,3-galactosyltransferase.
GalT2 (UDP-Gal:GA2/GM2/GD2 beta-1,3-galactosyltransferase) is a Golgi-resident type II membrane protein that participates in the… 
2006
2006
Cytoplasmic Tails of SialT2 and GalNAcT Impose Their Respective Proximal and Distal Golgi Localization
Complex glycolipid synthesis is catalyzed by different glycosyltransferases resident of the Golgi complex. Most of them are type… 
2006
2006
The wbnH gene of Escherichia coli O86:H2 encodes an alpha-1,3-N-acetylgalactosaminyl transferase involved in the O-repeating unit biosynthesis.
Highly Cited
2005
Highly Cited
2005
Enhanced Susceptibility to Kainate-Induced Seizures, Neuronal Apoptosis, and Death in Mice Lacking Gangliotetraose Gangliosides: Protection with LIGA 20, a Membrane-Permeant Analog of GM1
Knock-out (KO) mice lacking gangliotetraose gangliosides attributable to disruption of the gene for GM2/GD2 synthase [GalNAcT… 
2000
2000
CHANGES IN LIVER GANGLIOSIDES IN STREPTOZOTOCIN‐INDUCED DIABETIC RATS
Diabetes mellitus is associated with various structural and functional liver abnormalities that affect the glycogen and lipid… 
1998
1998
Two soluble glycosyltransferases glycosylate less efficiently in vivo than their membrane bound counterparts.
Many Golgi glycosyltransferases are type II membrane proteins which are cleaved to produce soluble forms that are released from… 
1996
1996
β1,4-N-Acetylgalactosaminyltransferase (GM2 Synthase) Is Released from Golgi Membranes as a Neuraminidase-sensitive, Disulfide-bonded Dimer by a Cathepsin D-like Protease*
Many Golgi membrane-bound glycosyltransferases are released from cells in a soluble form. To characterize this release process… 
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