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The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity.
TLDR
This is the first demonstration that galectin-8 binds to specific sulfated or sialylated glycosphingolipids with high affinity, indicating that this Gln47 plays important roles for binding to Neu5Acalpha2-->3Gal or SO3--->3Gal residues. Expand
Galectin-8-N-domain Recognition Mechanism for Sialylated and Sulfated Glycans*
TLDR
This study elucidated the crystal structures of the human galectin-8-N-domain (-8N) in the absence or presence of 4 ligands and found that Arg45, Gln47, Arg59, and the long loop region between the S3 and S4 β-strands are unique to galectIn-8N. Expand
Galectin-4 Binds to Sulfated Glycosphingolipids and Carcinoembryonic Antigen in Patches on the Cell Surface of Human Colon Adenocarcinoma Cells*
TLDR
It is found that galectin-4 binds to glycosphingolipids carrying 3-O-sulfated Gal residues, such as SB1a, SM3, SM4s, SB2, SM2a, and GM1, but not to Glycobiology residues with 3- O-sialylated Gal, using both an enzyme-linked immunosorbent assay and a surface plasmon resonance assay. Expand
Occurence of a sialylglycopeptide and free sialylglycans in hen's egg yolk.
TLDR
Since the molar value of SGP present in one egg yolk is comparable to those of well-known major yolk proteins, low density lipoprotein, lipovitellins and phosvitin, it can be considered that SGP is one of the major components in hen's egg yolks. Expand
Purification and enzymatic properties of peptide:N-glycanase from C3H mouse-derived L-929 fibroblast cells. Possible widespread occurrence of post-translational remodification of proteins by
TLDR
It is proposed here that PNGase-catalyzed N-deglycosylation is a functionally important universal feature in living cells. Expand
Vesicular-integral membrane protein, VIP36, recognizes high-mannose type glycans containing alpha1-->2 mannosyl residues in MDCK cells.
TLDR
Results indicate that VIP36 functions as an intracellular lectin recognizing glycoproteins which possess high-mannose type glycans, (Manalpha1-->2)(2-4).Man(5). Expand
Identification of peptide:N-glycanase activity in mammalian-derived cultured cells.
TLDR
This represents the first demonstration of PNGase in mammalian cells and thus PNGase appears to be a very common enzyme expressed in not only plants and bacteria but also a wide range of animals although its functional significance remains to be clarified. Expand
High-affinity binding of recombinant human galectin-4 to SO3–→3Galβ1→3GalNAc pyranoside
Galectin-4 is a member of galectin family and has two carbohydrate recognition domains. Although galectin-4 has been thought to function in cell adhesion, its precise carbohydrate binding specificityExpand
Functional analysis of endoplasmic reticulum glucosyltransferase (UGGT): Synthetic chemistry's initiative in glycobiology.
TLDR
It is demonstrated that high-mannose-type glycans, in which various hydrophobic aglycons were introduced, act as good substrates for UGGT1 and are useful analytical tools for its characterization and it is found that U GGT2, an isoform UggT1, is also capable of glucosylating these synthetic substrates. Expand
Novel O-linked glycans containing 6'-sulfo-Gal/GalNAc of MUC1 secreted from human breast cancer YMB-S cells: possible carbohydrate epitopes of KL-6(MUC1) monoclonal antibody.
TLDR
The results indicated that the possible carbohydrate epitopes of KL-6/mAb involve not only 3'-sialylated core 1 but also novel core 1 and extended core 1 with sulfate and sialic acid residues. Expand
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