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Butyrylcholinesterase is a promiscuous enzyme that displays complex kinetic behavior. It is toxicologically important because it… Expand Steady-state kinetics for the hydrolysis of benzoylcholine (BzCh) and benzoylthiocholine (BzSCh) by wild-type human… Expand Abstract: A recent study has linked the butyrylcholinesterase (BChE) K‐variant and the apolipoprotein ε4 isoform to late‐onset… Expand Irinotecan (CPT-11) is an anticancer drug that occasionally produces acute cholinergic side effects. Preliminary findings suggest… Expand Butyrylcholinesterase (BChE) has a major role in cocaine detoxication. The rate at which human BChE hydrolyzes cocaine is slow… Expand The G117H mutant of human butyrylcholinesterase (EC 220.127.116.11) was expressed in Chinese hamster ovary cells. Substitution of Gly… Expand Serum cholinesterase (ChE) (E.C. 18.104.22.168) is a glycoprotein which has 36 potential sites of asparagine-N-linked sugar chains. The… Expand Abstract Hydrolysis of cocaine to ecgonine methyl ester in human plasma is mediated by cholinesterase. Cocaine hydrolysis by… Expand IT has been shown that individuals excessively sensitive to the drug suxamethonium have a reduced level of serum cholinesterase… Expand A method for the assay of human serum cholinesterase (pseudocholinesterase) is described in detail. The disappearance of… Expand