Basal-Like Breast Carcinoma

Known as: Basal-Like Breast Cancer, Basal-Like Subtype of Breast Carcinoma 
A biologic subset of breast carcinoma defined by high expression of genes characteristic of basal epithelial cells, including KRT5 and KRT17, annexin… (More)
National Institutes of Health

Related topics

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11 relations
BreastEGFR Protein OverexpressionEGFR geneEpithelial Cells
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Papers overview

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Highly Cited
2011
Highly Cited
2011
A clinically relevant gene signature in triple negative and basal-like breast cancer
Current prognostic gene expression profiles for breast cancer mainly reflect proliferation status and are most useful in ER… (More)
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Highly Cited
2011
Highly Cited
2011
CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer
Tumor infiltrating lymphocytes may indicate an immune response to cancer development, but their significance remains… (More)
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Highly Cited
2010
Highly Cited
2010
Genome Remodeling in a Basal-like Breast Cancer Metastasis and Xenograft
Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes… (More)
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Highly Cited
2010
Highly Cited
2010
Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma.
AIMS Monocarboxylate transporters (MCTs) have been considered promising targets for cancer therapy, since they facilitate lactate… (More)
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Highly Cited
2010
Highly Cited
2010
Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer
Triple-negative breast cancer, defined as that with negative expression of estrogen and progesterone receptors and cerbB2… (More)
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Highly Cited
2009
Highly Cited
2009
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.
PURPOSE The pathways underlying basal-like breast cancer are poorly understood, and as yet, there is no approved targeted therapy… (More)
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Highly Cited
2008
Highly Cited
2008
Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
Basal-like carcinomas (BLCs) and human epidermal growth factor receptor 2 overexpressing (HER2+) carcinomas are the subgroups of… (More)
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Highly Cited
2007
Highly Cited
2007
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland.
High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no data are available on the… (More)
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Highly Cited
2007
Highly Cited
2007
BRCA1 dysfunction in sporadic basal-like breast cancer
Basal-like breast cancers form a distinct subtype of breast cancer characterized by the expression of markers expressed in normal… (More)
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Highly Cited
2007
Highly Cited
2007
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.
Women carrying germ-line mutations in BRCA1 are strongly predisposed to developing breast cancers with characteristic features… (More)
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