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BTK gene

Known as: BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE, Bruton tyrosine kinase, XLA 
This gene is involved in both signaling and B-cell development.
National Institutes of Health

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Agammaglobulinaemia tyrosine kinaseBTK protein, humanCell Differentiation processCell Proliferation

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BTK wt Allele

Papers overview

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Highly Cited
2016
Highly Cited
2016
Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma
Acalabrutinib (ACP-196) is a second-generation inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK) with increased target… 
Review
2016
Review
2016
Bruton tyrosine kinase inhibition in chronic lymphocytic leukemia.
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and remains incurable outside of the setting of allogeneic… 
2016
2016
A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells
ABSTRACT Ibrutinib, a BTK inhibitor, is currently used to treat various hematological malignancies. We evaluated whether… 
Highly Cited
2015
Highly Cited
2015
Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia.
Despite the therapeutic efficacy of ibrutinib in chronic lymphocytic leukemia (CLL), complete responses are infrequent, and… 
2014
2014
Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.
2007
2007
Bruton's tyrosine kinase (BTK) is a binding partner for hypoxia induced mitogenic factor (HIMF/FIZZ1) and mediates myeloid cell chemotaxis
Hypoxia induced mitogenic factor (HIMF) is a member of the FIZZ/resistin/RELM family of proteins that we have shown to have… 
2001
2001
Phenotypic analysis of conditionally immortalized cells isolated from the BPK model of ARPKD.
To study the pathophysiology of autosomal recessive polycystic kidney disease (ARPKD), we sought to develop conditionally… 
Highly Cited
1994
Highly Cited
1994
Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci.
Btk is a cytoplasmic protein tyrosine kinase (PTK) that has been directly implicated in the pathogenesis of X-linked… 
1994
1994
Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22.
A regional physical and transcription map involving yeast artificial chromosomes (YACs), cosmids, and cDNAs has been constructed… 
1993
1993
Sequence analysis of human T cell lymphotropic virus type I strains from southern India: gene amplification and direct sequencing from whole blood blotted onto filter paper.
Human T cell lymphotropic virus type I (HTLV-I) infection in India has been found to be associated with adult T cell leukaemia… 
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