BTK gene

Known as: BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE, Bruton tyrosine kinase, XLA 
This gene is involved in both signaling and B-cell development.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
UNLABELLED Despite the unprecedented clinical activity of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib in mantle cell… (More)
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Highly Cited
2014
Highly Cited
2014
Chronic lymphocytic leukemia (CLL) is characterized by constitutive activation of the B-cell receptor (BCR) signaling pathway… (More)
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2013
2013
Resistance to the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related… (More)
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Highly Cited
2008
Highly Cited
2008
Despite identification of the genes responsible for autosomal dominant polycystic kidney disease (PKD) and autosomal recessive… (More)
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Highly Cited
2000
Highly Cited
2000
Mutations in the gene encoding Bruton's tyrosine kinase (btk) cause the B cell deficiency diseases X-linked agammaglobulinemia… (More)
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Highly Cited
1996
Highly Cited
1996
Bruton's tyrosine kinase (BTK) is pivotal in B cell activation and development through its participation in the signaling… (More)
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Highly Cited
1996
Highly Cited
1996
Polycyclic aromatic compounds (PAC) are ubiquitous pollutants in urban air that may pose risks to human health. In order to… (More)
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Highly Cited
1995
Highly Cited
1995
Bruton's tyrosine kinase (BTK) is a nonreceptor tyrosine kinase critical for B cell development and function. Mutations in BTK… (More)
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Highly Cited
1994
Highly Cited
1994
To identify the novel receptor tyrosine kinases (RTKs) critical to the proliferation of hematopoietic stem cells, we performed… (More)
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Highly Cited
1993
Highly Cited
1993
We describe a novel cytoplasmic tyrosine kinase, termed BPK (B cell progenitor kinase), which is expressed in all stages of the B… (More)
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