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BPIFA1 protein, human

Known as: SPLUNC1 protein, human, lung-specific X protein, human, LUNX protein, human 
BPI fold-containing family A member 1 (256 aa, ~27 kDa) is encoded by the human BPIFA1 gene. This protein may be involved in innate immunity in the… 
National Institutes of Health

Related topics

Related topics

9 relations
Antibacterial ResponseApical Domain of the EpitheliumBPIFA1 geneExtracellular Protein

Broader (2)

GlycoproteinsPhosphoproteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, α4-Short, in a Murine Model of Respiratory Infection
The rise of superbugs underscores the urgent need for novel antimicrobial agents. Antimicrobial peptides (AMPs) have the ability… 
2014
2014
SPLUNC1 is associated with nasopharyngeal carcinoma prognosis and plays an important role in all‐trans‐retinoic acid‐induced growth inhibition and differentiation in nasopharyngeal cancer cells
Human SPLUNC1 can suppress nasopharyngeal carcinoma (NPC) tumor formation; however, the correlation between SPLUNC1expression and… 
Highly Cited
2013
Highly Cited
2013
Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways
Significance Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene… 
Highly Cited
2013
Highly Cited
2013
Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria
Background Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD… 
Highly Cited
2012
Highly Cited
2012
Multifunctional Role of Human SPLUNC1 in Pseudomonas aeruginosa Infection
ABSTRACT The human short PLUNC1 (SPLUNC1) protein has been identified as a component of the pulmonary antimicrobial response… 
2012
2012
Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways.
The epithelial sodium channel (ENaC) is responsible for Na+ and fluid absorption across colon, kidney, and airway epithelia. We… 
Review
2011
Review
2011
Functional roles of SPLUNC1 in the innate immune response against Gram-negative bacteria.
PLUNC (palate, lung and nasal epithelium clone)-associated gene originally referred to one gene, but now has been extended to… 
Highly Cited
2007
Highly Cited
2007
Function and Regulation of SPLUNC1 Protein in Mycoplasma Infection and Allergic Inflammation1
Respiratory infections, including Mycoplasma pneumoniae (Mp), contribute to asthma pathobiology. To date, the mechanisms… 
Highly Cited
2007
Highly Cited
2007
Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis
IntroductionShort PLUNC1 (SPLUNC1) is the founding member of a family of proteins (PLUNCS) expressed in the upper respiratory… 
2005
2005
Porcine SPLUNC1: molecular cloning, characterization and expression analysis.
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