All Fields
Computer Science
Medicine
FAQ
Contact
Sign in
BMS-911543
Known as:
JAK2 Inhibitor BMS-911543
Â
An orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS…Â
(More)
National Institutes of Health
Topic mentions per year
Topic mentions per year
2012-2014
0
1
2
2012
2014
Related topics
Related topics
1 relation
Receptor Tyrosine Kinase Inhibition
Related mentions per year
Related mentions per year
2010-2017
2010
2012
2014
2016
2018
2020
BMS-911543
Receptor Tyrosine Kinase Inhibition
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.
Thomas A R Mace
,
R. Shakya
,
+10 authors
Gregory B. Lesinski
Oncotarget
2015
The Jak/STAT pathway is activated in human pancreatic ductal adenocarcinoma (PDAC) and cooperates with mutant Kras to drive…Â
(More)
Is this relevant?
2015
2015
Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm.
Anthony D. Pomicter
,
Anna M. Eiring
,
+5 authors
Michael W. N. Deininger
Experimental hematology
2015
Activation of Janus kinase 2 (JAK2), frequently as a result of the JAK2(V617F) mutation, is a characteristic feature of the…Â
(More)
Is this relevant?
2015
2015
Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.
Honghe Wan
,
Gretchen M Schroeder
,
+32 authors
Ashok V Purandare
ACS medicinal chemistry letters
2015
JAK2 kinase inhibitors are a promising new class of agents for the treatment of myeloproliferative neoplasms and have potential…Â
(More)
Is this relevant?
2015
2015
Ni-Catalyzed C-H Functionalization in the Formation of a Complex Heterocycle: Synthesis of the Potent JAK2 Inhibitor BMS-911543.
Monica A Fitzgerald
,
Omid Soltani
,
+10 authors
Martin D Eastgate
The Journal of organic chemistry
2015
BMS-911543 is a complex pyrrolopyridine investigated as a potential treatment for myeloproliferative disorders. The development…Â
(More)
Is this relevant?
2015
2015
A UHPLC-MS/MS bioanalytical assay for the determination of BMS-911543, a JAK2 inhibitor, in human plasma.
Jane Liu
,
Long Yuan
,
+4 authors
Qin Ji
Journal of chromatography. B, Analytical…
2015
Herein we report a rapid, accurate and robust UHPLC-MS/MS assay for the quantitation of BMS-911453, a Janus kinase 2 inhibitor…Â
(More)
Is this relevant?
2015
2015
Integration of Physiologically-Based Pharmacokinetic Modeling into Early Clinical Development: An Investigation of the Pharmacokinetic Nonlinearity
L. Zhou
,
Jay Gan
,
+4 authors
W Griffith Humphreys
CPT: pharmacometrics & systems pharmacology
2015
BMS-911543, a promising anticancer agent, exhibited time-dependent and dose-dependent nonlinear pharmacokinetics (PKs) in its…Â
(More)
Is this relevant?
2014
2014
BMS-911543 inhibits viability of tumor and stromal cells and limits disease progression in genetically engineered mice with pancreatic cancer
Thomas A R Mace
,
R. Shakya
,
+10 authors
Gregory B. Lesinski
2014
Pancreatic cancer (PCa) is resistant to cytotoxic therapies, and the profound immune suppressive nature of this disease renders…Â
(More)
Is this relevant?
2014
2014
Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells
Hanyang Lin
,
Min Chen
,
Katharina Rothe
,
Matthew V. Lorenzi
,
Adrian Woolfson
,
Xiaoyan Jiang
Oncotarget
2014
Imatinib Mesylate (IM) and other tyrosine kinase inhibitor (TKI) therapies have had a major impact on the treatment of chronic…Â
(More)
Is this relevant?
2012
2012
Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2
Ashok V Purandare
,
T M Mcdevitt
,
+26 authors
Matthew V. Lorenzi
Leukemia
2012
We report the characterization of BMS-911543, a potent and selective small-molecule inhibitor of the Janus kinase (JAK) family…Â
(More)
Is this relevant?
Review
2012
Review
2012
Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application
Muhammad Furqan
,
Nikhil Mukhi
,
Byung Lee
,
Delong Liu
Biomarker Research
2012
JAK-STAT (Janus associated kinase-signal transducer and activator of transcription) pathway plays a critical role in transduction…Â
(More)
Is this relevant?