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BMS-911543

Known as: JAK2 Inhibitor BMS-911543 
An orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS… Expand
National Institutes of Health

Papers overview

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2015
2015
JAK2 kinase inhibitors are a promising new class of agents for the treatment of myeloproliferative neoplasms and have potential… Expand
2015
2015
Activation of Janus kinase 2 (JAK2), frequently as a result of the JAK2(V617F) mutation, is a characteristic feature of the… Expand
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2015
2015
The Jak/STAT pathway is activated in human pancreatic ductal adenocarcinoma (PDAC) and cooperates with mutant Kras to drive… Expand
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2015
2015
BMS-911543 is a complex pyrrolopyridine investigated as a potential treatment for myeloproliferative disorders. The development… Expand
2015
2015
  • Jane Liu, L. Yuan, +4 authors Q. Ji
  • Journal of chromatography. B, Analytical…
  • 2015
  • Corpus ID: 5390613
Herein we report a rapid, accurate and robust UHPLC-MS/MS assay for the quantitation of BMS-911453, a Janus kinase 2 inhibitor… Expand
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2014
2014
Imatinib Mesylate (IM) and other tyrosine kinase inhibitor (TKI) therapies have had a major impact on the treatment of chronic… Expand
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2013
2013
Background BMS-911543 is an oral, selective small-molecule inhibitor of JAK2 (IC50=1.1nM) with potent anti-proliferative and… Expand
Highly Cited
2012
Highly Cited
2012
We report the characterization of BMS-911543, a potent and selective small-molecule inhibitor of the Janus kinase (JAK) family… Expand
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Review
2012
Review
2012
JAK-STAT (Janus associated kinase-signal transducer and activator of transcription) pathway plays a critical role in transduction… Expand
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2010
2010
Abstract 4112 We report the characterization of BMS-911543, a potent and functionally selective small molecule inhibitor of the… Expand