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BMS-906024

Known as: GS/pan-Notch Inhibitor BMS-906024 
An orally bioavailable, small-molecule gamma secretase (GS) and pan-Notch inhibitor, with potential antineoplastic activity. Upon administration, GS… Expand
National Institutes of Health

Papers overview

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2018
2018
Background: Lung cancer is the leading cause of cancer death worldwide. More effective treatments are needed to increase durable… Expand
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2018
2018
2515Background: Notch signaling can be deregulated in human cancer. AL101 (formerly BMS-906024), a gamma secretase inhibitor that… Expand
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2017
2017
Notch signaling is aberrantly activated in approximately one third of non–small cell lung cancers (NSCLC). We characterized the… Expand
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2016
2016
Notch signaling is aberrantly activated in approximately one third of non-small cell lung cancer (NSCLC) cases, primarily through… Expand
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2015
2015
Structure-activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides identified highly potent inhibitors… Expand
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2015
2015
Notch pathway antagonists such as γ-secretase inhibitors (GSIs) are being tested in diverse cancers, but exceptional responses… Expand
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2015
2015
Bioanalytical analysis of toxicokinetic and pharmacokinetic samples is an integral part of small molecule drugs development and… Expand
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2015
2015
Notch signaling is aberrantly activated in approximately one third of non-small cell lung cancer cases, primarily through loss of… Expand
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2014
2014
Background: Activating mutations in Notch receptors are found in multiple hematopoietic malignancies, including > 50% of patients… Expand
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2014
2014
Deregulation of the Notch pathway has been shown to be oncogenic in numerous tissue types including T-cell acute lymphoblastic… Expand
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