BMS-906024

Known as: GS/pan-Notch Inhibitor BMS-906024 
An orally bioavailable, small-molecule gamma secretase (GS) and pan-Notch inhibitor, with potential antineoplastic activity. Upon administration, GS… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2015-2017
012320152017

Papers overview

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2017
2017
Notch signaling is aberrantly activated in approximately one third of non-small cell lung cancers (NSCLC). We characterized the… (More)
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2015
2015
Structure-activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides identified highly potent inhibitors… (More)
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2015
2015
Notch pathway antagonists such as γ-secretase inhibitors (GSIs) are being tested in diverse cancers, but exceptional responses… (More)
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2015
2015
Bioanalytical analysis of toxicokinetic and pharmacokinetic samples is an integral part of small molecule drugs development and… (More)
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