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BMS-906024

Known as: GS/pan-Notch Inhibitor BMS-906024 
An orally bioavailable, small-molecule gamma secretase (GS) and pan-Notch inhibitor, with potential antineoplastic activity. Upon administration, GS… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Benzodiazepinones
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Perfluoroctanoic acid (PFOA) enhances NOTCH-signaling in an angiogenesis model of placental trophoblast cells.
2018
2018
Synergistic Effects of NOTCH/γ-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells
Background: Lung cancer is the leading cause of cancer death worldwide. More effective treatments are needed to increase durable… 
2018
2018
A phase I study of AL101, a pan-NOTCH inhibitor, in patients (pts) with locally advanced or metastatic solid tumors.
2515Background: Notch signaling can be deregulated in human cancer. AL101 (formerly BMS-906024), a gamma secretase inhibitor that… 
2017
2017
Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma
Notch signaling is aberrantly activated in approximately one third of non–small cell lung cancers (NSCLC). We characterized the… 
2016
2016
Abstract 4834: Preclinical analysis of the Notch gamma secretase inhibitor BMS-906024 in combination with chemotherapy in the treatment of lung adenocarcinoma
Notch signaling is aberrantly activated in approximately one third of non-small cell lung cancer (NSCLC) cases, primarily through… 
Highly Cited
2015
Highly Cited
2015
Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.
Structure-activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides identified highly potent inhibitors… 
2015
2015
Abstract 2535: Synergistic anti-tumor activity of the Notch gamma secretase inhibitor BMS-906024 and paclitaxel in the treatment of lung adenocarcinoma
Notch signaling is aberrantly activated in approximately one third of non-small cell lung cancer cases, primarily through loss of… 
2014
2014
The Safety and Activity of BMS-906024, a Gamma Secretase Inhibitor (GSI) with Anti-Notch Activity, in Patients with Relapsed T-Cell Acute Lymphoblastic Leukemia (T-ALL): Initial Results of a Phase 1…
Background: Activating mutations in Notch receptors are found in multiple hematopoietic malignancies, including > 50% of patients… 
2014
2014
Abstract 1643: BMS-983970, an oral pan-Notch inhibitor for the treatment of cancer
Deregulation of the Notch pathway has been shown to be oncogenic in numerous tissue types including T-cell acute lymphoblastic… 
2013
2013
Blog to Wikipedia to ChemSpider – Online Collaboration to Create a Wikipedia Article for BMS-906024
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