BMS-605339
National Institutes of Health
Papers overview
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NS3 protease plays a vital role in the replication of the hepatitis C virus (HCV). BMS‐605339 is a novel linear tetra‐peptide…
The discovery of a back-up to the hepatitis C virus NS3 protease inhibitor asunaprevir (2) is described. The objective of this…
Asunaprevir (ASV; BMS-650032), a low nanomolar inhibitor of the hepatitis C virus (HCV) NS3 protease, is currently under…
BMS-605339 is a potent HCV NS3 protease inhibitor that suppresses hepatitis C virus replication and was under investigation as an…
The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor of the NS3/4A enzyme is…
Objective We recently demonstrated that combination treatment with NS3 protease and NS5B polymerase inhibitors succeeded in…