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BMS 536924

Known as: BMS-536924, BMS536924 
National Institutes of Health

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2 relations

Broader (2)

BenzimidazolesPyridones

Papers overview

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2017
2017
Dual inhibition of IGF 1 R and ER enhances response to trastuzumab in HER 2 positive breast cancer cells
Although HER2 targeted therapies have improved prognosis for HER2 positive breast cancer, HER2 positive cancers which co-express… 
2013
2013
In-vitro growth inhibition of chemotherapy and molecular targeted agents in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common and challenging malignant disease. The prognosis is poor in patients… 
2012
2012
Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours
Insulin-like growth factor-1 receptor (IGF1R) signalling is implicated in resistance to trastuzumab. However, the benefit of co… 
2012
2012
A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation
ETV6-NTRK3 (EN), a chimeric tyrosine kinase generated by t(12;15) translocations, is a dominantly acting oncoprotein in diverse… 
Highly Cited
2011
Highly Cited
2011
ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway.
The insulin-like growth factor (IGF) 1 receptor (IGF1R) is an important therapeutic target under study in many cancers. Here, we… 
2010
2010
Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.
2010
2010
Activity in Childhood Sarcomas Modifiers of Insulin-like Growth Factor-1 Receptor Inhibitor Synthetic Lethality Screens Reveal RPS 6 and MST 1 R as Updated
2008
2008
Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious…
We previously reported that 1 (BMS-536924), a benzimidazole inhibitor of the insulin-like growth factor-1 receptor, had… 
2007
2007
Identification of sensitivity markers for BMS-536924, an inhibitor for insulin-like growth factor-1 receptor
3506 Background: Insulin-like growth factor-1 receptor (IGF-1R) signaling is an important regulator of mitogenesis… 
2005
2005
BMS-536924, a potent, small molecule inhibitor of the IGF-1 receptor in vitro and in vivo
Proc Amer Assoc Cancer Res, Volume 46, 2005 5976 The IGF-1 receptor (IGF-1R) is a transmembrane tyrosine kinase growth factor… 
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