BKT140

Known as: BL-8040, CXCR4 Antagonist BL-8040 
An orally bioavailable inhibitor of CXC Chemokine Receptor 4 (CXCR4) with potential antineoplastic activity. CXCR4 antagonist BL-8040 selectively… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2018
012320092018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
CXCR4 is a key player in the retention and survival of human acute myeloid leukemia (AML) blasts in the bone marrow (BM… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
2014
2014
PURPOSE CXCR4 plays an important role in the retention of stem cells within the bone marrow. BKT140 (4F-benzoyl-TN14003) is a 14… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
Is this relevant?
2014
2014
Functional role of CXCR4 in chronic myelogenous leukemia (CML) progression was evaluated. Elevated CXCR4 significantly increased… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
Purpose:CXCR4 plays an important role in the retention of stem cells within the bonemarrow. BKT140 (4F-benzoyl-TN14003) is a 14… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • table 2
Is this relevant?
2013
2013
PURPOSE Chemokine axis CXCR4/CXCL12 is critically involved in the survival and trafficking of normal and malignant B lymphocytes… (More)
Is this relevant?
2013
2013
Platelets are the terminal differentiation product of megakaryocytes (MKs). Cytokines, such as thrombopoietin (TPO), are known to… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2013
2013
Purpose:Chemokine axis CXCR4/CXCL12 is critically involved in the survival and trafficking of normal andmalignant B lymphocytes… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2012
2012
OBJECTIVES CXCR4/CXCL12 interactions promote non-small cell lung cancer (NSCLC) growth and dissemination. Furthermore, this axis… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2012
2012
2962 Background: Multiple myeloma (MM) is characterized by clonal proliferation of malignant plasma cells (PCs) in the bone… (More)
Is this relevant?
2011
2011
OBJECTIVE The chemokine receptor CXCR4 and its ligand CXCL12 are involved in the progression and dissemination of a diverse… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?