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BIX 02189

Known as: BIX-02189, BIX02189 
National Institutes of Health

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2 relations

Broader (2)

Aniline CompoundsIndoles

Papers overview

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2018
2018
Abstract 3915: Melatonin-tamoxifen hybrid ligands and their effects on breast cancer
Background: A dual melatonin and tamoxifen hybrid ligand (HL) was developed and shown to display uterine protective actions while… 
2017
2017
Neuregulin1β Effects on Brain Tissue via ERK5-Dependent MAPK Pathway in a Rat Model of Cerebral Ischemia–Reperfusion Injury
Neuregulin1β (NRG1β), a member of the excitomotor of tyrosine kinase receptor (erbB) family, was recently shown to play a… 
2017
2017
CHOP Deficiency Ameliorates ERK5 Inhibition-Mediated Exacerbation of Streptozotocin-Induced Hyperglycemia and Pancreatic β-Cell Apoptosis
Streptozotocin (STZ)-induced murine models of type 1 diabetes have been used to examine ER stress during pancreatic β-cell… 
2017
2017
Neuregulin1β Effects on Brain Tissue via ERK5-Dependent MAPK Pathway in a Rat Model of Cerebral Ischemia–Reperfusion Injury
Neuregulin1β (NRG1β), a member of the excitomotor of tyrosine kinase receptor (erbB) family, was recently shown to play a… 
2015
2015
ERK5 regulates basic fibroblast growth factor-induced type 1 plasminogen activator inhibitor expression and cell proliferation in lung fibroblasts.
2015
2015
Activator of G-protein Signaling 3 Controls Renal Epithelial Cell Survival and ERK5 Activation
Activator of G-protein signaling 3 (AGS3) is an accessory protein that functions to regulate the activation status of… 
2014
2014
[Involvement of ERK5 and JNK in the BMP9-induced differentiation of C3H10T1/2 cells into cardiomyocyte-like cells].
OBJECTIVE To investigate the roles of extracellular signal-regulated kinase 5 (ERK5) and c-Jun N-terminal kinase (JNK) in the… 
2012
2012
Cyclic fluid shear stress promotes osteoblastic cells proliferation through ERK5 signaling pathway
Fluid shear stress plays an important role in bone remodeling, however, the mechanism of mechanotransduction in bone tissue… 
2011
2011
Molecular Pathways Targeting the BMK 1 MAP Kinase Pathway in Cancer Therapy
The big mitogen activated protein kinase 1 (BMK1) pathway is the most recently discovered and leaststudiedmammalianmitogen… 
Review
2010
Review
2010
The Signaling Pathway Leading to Extracellular Signal-Regulated Kinase 5 (ERK5) Activation via G-Proteins and ERK5-Dependent Neurotrophic Effects
Extracellular signal-regulated kinases (ERKs) or mitogen-activated protein kinases (MAPKs) are involved in cellular proliferation… 
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