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BIIB022

Known as: Anti-IGF-1R Recombinant Monoclonal Antibody BIIB022, BIIB-022 
A recombinant, human monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity… Expand
National Institutes of Health

Related topics

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2 relations

Broader (1)

Monoclonal Antibodies
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
A phase 1, open-label, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in subjects with relapsed or refractory solid tumors
SummaryPurpose The IGF-1R signaling pathway has been implicated in multiple cancers as important for cell survival, proliferation… Expand
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Review
2012
Review
2012
The role of the insulin-like growth factor signaling pathway in non-small cell lung cancer and other solid tumors.
The type 1 insulin-like growth factor receptor (IGF-1R) and its downstream signaling components have become increasingly… Expand
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Review
2011
Review
2011
Plasma and tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases: A review
  • E. E. Ozkan
  • Molecular and Cellular Endocrinology
  • 2011
    • Corpus ID: 37296132
Cancer database analysis indicates that prostate cancer is one of the most seen cancers in men meanwhile composing the leading… Expand
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2010
2010
Phase I, dose-escalation study of BIIB022 (anti-IGF-1R antibody) in advanced solid tumors.
2612 Background: The IGF pathway is believed to play a key role in the pathogenesis of several tumors. BIIB022 is a human… Expand
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2009
2009
Dyax and Biogen Idec Expand Drug Discovery Deal
Biogen Idec has expanded its agreement to discover additional antibody products using Dyax’s phage display drug discovery… Expand
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2009
2009
1227 A phase 1, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in patients with relapsed or refractory solid tumours
 
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Review
2009
Review
2009
Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine.
The insulin-like growth factor 1 receptor (IGF-1R) and its associated signalling system has provoked considerable interest over… Expand
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2008
2008
BIIB022, a human antibody targeting human insulin-like growth factor-1 receptor (IGF-1R), enhances the anti-tumor activities of Tarceva in non-small cell lung carcinoma (NSCLC) and Rapamycin in…
4002 Antibodies to IGF-1R as inhibitors of PI3K/AKT survival pathway have shown evidence of objective responses in early clinical… Expand
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2007
2007
BIIB022, a fully human nonglycosylated γ4P antibody targeting IGF-1R for cancer therapy
B210 Antibodies targeting human type I insulin-like growth factor receptor (IGF-1R) as inhibitors of tumor survival pathway have… Expand
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