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BH 3

Known as: 4-(1-aminoethyl)-2,6-bis(1,1-dimethylethyl)phenol, BH-3 
National Institutes of Health

Related topics

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2 relations

Broader (1)

Butylated Hydroxytoluene
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic
Despite recent advances, treatment options for advanced prostate cancer (CaP) remain limited. We are pioneering approaches to… 
2015
2015
Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo
Despite great efforts taken to advance therapeutic measures for patients with glioblastoma, the clinical prognosis remains grim… 
2014
2014
A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer
SummaryBackground. A phase I, dose-escalation study of AT-101 with cisplatin and etoposide was conducted to determine the maximum… 
2013
2013
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma cells
Correction to: Cell Death and Disease (2013) 4, e489; doi:10.1038/cddis.2013.17; published online 7 February 2013 Since the… 
2013
2013
Combination treatments with ABT‐263 and an immunotoxin produce synergistic killing of ABT‐263‐resistant small cell lung cancer cell lines
Synergistic killing was achieved when Small Cell Lung Cancer (SCLC) cell lines were incubated with ABT‐263 and an immunotoxin… 
2012
2012
Gefitinib Analogue V1801 Induces Apoptosis of T790M EGFR-Harboring Lung Cancer Cells by Up-Regulation of the BH-3 Only Protein Noxa
Treatment of non-small cell lung cancer (NSCLC) with drugs targeting the epidermal growth factor receptor (EGFR), e.g., gefitinib… 
Highly Cited
2011
Highly Cited
2011
Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1.
Solid tumors contain hypoxic regions in which cancer cells are often resistant to chemotherapy-induced apoptotic cell death… 
Review
2010
Review
2010
Apoptosis in pre-Bilaterians: Hydra as a model
Hydra is a member of the ancient metazoan phylum Cnidaria and is an especially well investigated model organism for questions of… 
Review
2009
Review
2009
Emerging role of tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL) as a key regulator of inflammatory responses
1. Tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL) induces apoptosis in tumour cells while leaving most non… 
Review
2003
Review
2003
Mitochondrial membrane permeabilisation by Bax/Bak.
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