BCX4430
National Institutes of Health
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Two new C-nucleoside analogues, BCX4430, an imino-C-nucleoside, and GS-6620, a phosphoramidate derivative of 1'-cyano-2'-C-methyl…
Ebola is a deadly virus that has recently emerged as an enormous public health concern which causes dangerous illness with high…
Ebola virus is a single-stranded, negative-sense RNA virus that causes severe hemorrhagic fever in humans and nonhuman primates…
In a recent study published in Nature, Warren et al. describe the generation of a novel synthetic adenosine analogue, BCX4430, a…
The current Ebola virus outbreak is unprecedented in its scope and international impact. Given that there are currently no…
The 2014 outbreak clearly showed that Ebola viruses (EBOV) remain a substantial threat for public health. The mainstay of…
Marburg and Ebola hemorrhagic fevers are severe, systemic viral diseases affecting humans and non-human primates. They are…
LETTER TO THE EDITORKey words: Ebola, Ebola hemorrhagic fever, case fatality rate, epidemicSince 1976, most epidemiological…
本发明揭示了一种抗埃博拉病毒药物BCX4430(I)的制备方法，其制备步骤包括：2,5‑二甲氧基‑3S,4R‑二乙酰氧基四氢呋喃、(S)‑1‑(α‑氨基苄基)‑2‑萘酚以及苯并三氮唑发生环合反应生成(1S,3R,4S,5S,6S)‑1‑苯基‑3‑(1…