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BBSome

Known as: Bardet-Biedl syndrome complex, Bardet-Biedl syndrome complex location 
A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2… 
National Institutes of Health

Papers overview

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2020
2020
Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding
Cilia both receive and send information, the latter in the form of extracellular vesicles (EVs). EVs are nano-communication… 
Review
2018
Review
2018
Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motors.
Cilia and flagella of eukaryotic cells are evolutionarily conserved organelles with a microtubule-based axoneme as a scaffold. To… 
Highly Cited
2014
Highly Cited
2014
IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment.
Highly Cited
2013
Highly Cited
2013
Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase
The BBSome, a regulator of ciliary membrane protein composition, is required only for the export phase of a process that… 
Highly Cited
2013
Highly Cited
2013
BBS7 is required for BBSome formation and its absence in mice results in Bardet-Biedl syndrome phenotypes and selective abnormalities in membrane protein trafficking
Summary Bardet-Biedl Syndrome (BBS) is a pleiotropic and genetically heterozygous disorder caused independently by numerous genes… 
Highly Cited
2012
Highly Cited
2012
The BBSome controls IFT assembly and turnaround in cilia
The bidirectional movement of intraflagellar transport (IFT) particles, which are composed of motors, IFT-A and IFT-B… 
Highly Cited
2012
Highly Cited
2012
Exome sequencing identifies mutations in LZTFL1, a BBSome and smoothened trafficking regulator, in a family with Bardet–Biedl syndrome with situs inversus and insertional polydactyly
Background Bardet–Biedl Syndrome (BBS) is an emblematic recessive genetically highly heterogeneous ciliopathy characterised… 
Highly Cited
2011
Highly Cited
2011
A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened
Many signaling proteins including G protein-coupled receptors localize to primary cilia, regulating cellular processes including… 
Highly Cited
2010
Highly Cited
2010
BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly
Bardet-Biedl syndrome (BBS) is a human genetic disorder resulting in obesity, retinal degeneration, polydactyly, and nephropathy… 
Highly Cited
2008
Highly Cited
2008
A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.
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