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Abstract. The metalloenzyme peptide deformylase (PDF) catalyzes the elimination of the N-formyl group from N-terminal methionine… Expand BB-83698 is a first potent inhibitor of peptide deformylase in this novel class to enter clinical trials. In this study… Expand The relatively rapid development of microbial resistance after the entry of every new antimicrobial into the marketplace… Expand Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth but is not required by mammalian… Expand The metalloenzyme peptide deformylase (PDF) represents one of the most promising bacterial targets in the search for novel mode… Expand OBJECTIVES
BB-83698 is a peptide deformylase inhibitor currently in clinical trials in Europe. The purpose of this study was to… Expand ABSTRACT The efficacy of BB-83698, a novel potent peptide deformylase inhibitor, was evaluated in a mouse model of acute… Expand Sir, Bacterial peptide deformylase (PDF) belongs to a subfamily of metalloproteases catalysing the removal of the N-terminal… Expand ABSTRACT BB-83698, a potent and selective inhibitor of peptide deformylase, was the first compound of this novel antibacterial… Expand ABSTRACT The activities of six peptide deformylase (PDF) inhibitors against 107 respiratory tract pathogens were studied and… Expand