BB-83698
National Institutes of Health
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Abstract. The metalloenzyme peptide deformylase (PDF) catalyzes the elimination of the N-formyl group from N-terminal methionine…
The relatively rapid development of microbial resistance after the entry of every new antimicrobial into the marketplace…
Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth but is not required by mammalian…
OBJECTIVES
BB-83698 is a peptide deformylase inhibitor currently in clinical trials in Europe. The purpose of this study was to…
ABSTRACT The efficacy of BB-83698, a novel potent peptide deformylase inhibitor, was evaluated in a mouse model of acute…
Sir, Bacterial peptide deformylase (PDF) belongs to a subfamily of metalloproteases catalysing the removal of the N-terminal…
ABSTRACT BB-83698, a potent and selective inhibitor of peptide deformylase, was the first compound of this novel antibacterial…
ABSTRACT The activities of six peptide deformylase (PDF) inhibitors against 107 respiratory tract pathogens were studied and…