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BACH2 gene

Known as: BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR 2, BTBD25, BACH2 
This gene is involved in the modulation of transcription.
National Institutes of Health

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5 relations
BACH2 protein, humanHomo sapiensTranscriptional Regulationdna binding

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BACH2 wt Allele

Papers overview

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Highly Cited
2018
Highly Cited
2018
SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
Regulatory T (Treg) cells are essential for maintaining immune homeostasis and tolerance, but the mechanisms regulating the… 
Highly Cited
2017
Highly Cited
2017
BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency
The transcriptional programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription… 
Highly Cited
2014
Highly Cited
2014
BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic β-Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2
Type 1 diabetes is a chronic autoimmune disease characterized by specific destruction of pancreatic β-cells by the immune system… 
Highly Cited
2013
Highly Cited
2013
Bach2 maintains T cells in a naive state by suppressing effector memory-related genes
The transcriptional repressor BTB and CNC homology 2 (Bach2) is thought to be mainly expressed in B cells with specific functions… 
Highly Cited
2013
Highly Cited
2013
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint
The B cell–specific transcription factor BACH2 is required for affinity maturation of B cells. Here we show that Bach2-mediated… 
Highly Cited
2013
Highly Cited
2013
Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics
We have reported previously that duodenal follicular lymphoma (FL) is distinct from nodal FL and showed more resemblance to… 
Highly Cited
2006
Highly Cited
2006
Plasmacytic Transcription Factor Blimp-1 Is Repressed by Bach2 in B Cells*
Bach2 is a B cell-specific transcription repressor whose deficiency in mice causes a reduced class switch recombination and a… 
Highly Cited
2004
Highly Cited
2004
The transcriptional programme of antibody class switching involves the repressor Bach2
Activated B cells differentiate to plasma cells to secrete IgM or, after undergoing class switch recombination (CSR), to secrete… 
Highly Cited
1998
Highly Cited
1998
Identification of Bach2 as a B‐cell‐specific partner for small Maf proteins that negatively regulate the immunoglobulin heavy chain gene 3′ enhancer
Maf family transcription factors are important regulators in various differentiation systems. Putative Maf recognition elements… 
Highly Cited
1966
Highly Cited
1966
An expanded test for speech discrimination utilizing CNC monosyllabic words. Northwestern University Auditory Test No. 6. SAM-TR-66-55.
Abstract : Northwestern University Auditory Test No. 6 is composed of four lists of 50 consonant-nucleus-consonant (CNC… 
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