The transcriptional programme of antibody class switching involves the repressor Bach2

@article{Muto2004TheTP,
  title={The transcriptional programme of antibody class switching involves the repressor Bach2},
  author={Akihiko Muto and Satoshi Tashiro and Osamu Nakajima and Hideto Hoshino and Satoru Takahashi and Eiichirou Sakoda and Dai Ikebe and Masayuki Yamamoto and Kazuhiko Igarashi},
  journal={Nature},
  year={2004},
  volume={429},
  pages={566-571}
}
Activated B cells differentiate to plasma cells to secrete IgM or, after undergoing class switch recombination (CSR), to secrete other classes of immunoglobulins. Diversification of antibody function by CSR is important for humoral immunity. However, it remains unclear how the decision for the bifurcation is made. Bach2 is a B-cell-specific transcription repressor interacting with the small Maf proteins whose expression is high only before the plasma cell stage. Here we show that Bach2 is… CONTINUE READING

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Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics

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Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network.

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