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Antigen-dependent engagement of germinal center (GC) B cell receptors (BCRs) promotes antigen internalization and presentation… Expand Upon antigen encounter, the responsive B cell pool undergoes stringent selection which eliminates cells with low B cell receptor… Expand Antigen receptor–mediated production of inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) in lymphocytes triggers the release of Ca2… Expand Complement receptor type 2 (CR2) is a receptor that serves as an important interface between the complement system and adaptive… Expand Immunoglobulins undergoing cold-dependent precipitation are known as cryoglobulins. A type I cryoglobulin after Brouet et al… Expand The B-cell antigen receptor (BCR) is essential for B-cell selection, expansion, differentiation, and antigen presentation. The… Expand Antibody affinity for antigen is believed to govern B lymphocyte selection during T-dependent immune responses. To examine… Expand Experimental evidence contradicts the simplistic view that during development all B cells expressing non autoreactive antigen… Expand The immune system appears to be rigid, restricting one lymphocyte to make one antibody (()) and the peripheral B cell pool… Expand Apoptosis (programmed cell death) has been suggested to be involved in clonal elimination of self-reactive lymphocytes for the… Expand