Axon Initial Segment

Known as: Axon Initial Segments, Initial segment of axon, initial segment 
First segment of axon that connects distal axon segments to the neuronal CELL BODY at the axon hillock region. The axon initial segment is not… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
In neurons, the axon initial segment (AIS) is a specialized region near the start of the axon that is the site of action… (More)
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Highly Cited
2010
Highly Cited
2010
Deprivation of afferent inputs in neural circuits leads to diverse plastic changes in both pre- and postsynaptic elements that… (More)
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Highly Cited
2009
Highly Cited
2009
Distinct molecules are segregated into somatodendritic and axonal compartments of polarized neurons, but mechanisms underlying… (More)
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Highly Cited
2008
Highly Cited
2008
The exact site of initiation and shape of action potentials vary among different neuronal types. The reason for this variability… (More)
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Highly Cited
2008
Highly Cited
2008
The axon initial segment (AIS) is a specialized region in neurons where action potentials are initiated. It is commonly assumed… (More)
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Highly Cited
2008
Highly Cited
2008
The axon initial segment (AIS) functions as both a physiological and physical bridge between somatodendritic and axonal domains… (More)
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Highly Cited
2007
Highly Cited
2007
Action potentials are binary signals that transmit information via their rate and temporal pattern. In this context, the axon is… (More)
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Highly Cited
2007
Highly Cited
2007
Action potential initiation and propagation requires clustered Na(+) (voltage-gated Na(+) [Nav]) channels at axon initial… (More)
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Highly Cited
2007
Highly Cited
2007
Voltage-gated sodium (Na(v)) channels accumulate at the axon initial segment (IS), where their high density supports spike… (More)
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Highly Cited
1996
Highly Cited
1996
A long-standing hypothesis is that action potentials initiate first in the axon hillock/initial segment (AH-IS) region because of… (More)
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