Ataxin-3

Known as: Spinocerebellar Ataxia 3 Protein, Ataxin 3, Ataxin 3 Protein 
A deubiquitinating enzyme of the ATAXINS family. It functions in protein homeostasis, GENETIC TRANSCRIPTION; CYTOSKELETON regulation, and MYOGENESIS… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Machado–Joseph disease (MJD; also called spinocerebellar ataxia type 3) is a dominantly inherited late-onset neurodegenerative… (More)
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Highly Cited
2010
Highly Cited
2010
Spinocerebellar ataxia type 3 is a neurodegenerative disorder caused by the expansion of the polyglutamine repeat region within… (More)
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Highly Cited
2008
Highly Cited
2008
Polyglutamine (polyQ) diseases are a class of dominantly inherited neurodegenerative disorders caused by the expansion of a CAG… (More)
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Highly Cited
2007
Highly Cited
2007
Spinocerebellar ataxia type-3 (SCA3) is among the most common dominantly inherited ataxias, and is one of nine devastating human… (More)
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Highly Cited
2005
Highly Cited
2005
The polyglutamine-containing neurodegenerative protein ataxin 3 (AT3) has deubiquitylating activity and binds ubiquitin chains… (More)
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Highly Cited
2005
Highly Cited
2005
Two central issues in polyglutamine-induced neurodegeneration are the influence of the normal function of the disease protein and… (More)
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2004
2004
Spinocerebellar ataxia types 2 (SCA2) and 3 (SCA3) are autosomal-dominantly inherited, neurodegenerative diseases caused by CAG… (More)
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Highly Cited
2003
Highly Cited
2003
The ubiquitin-proteasome pathway is critically involved in the pathology of neurodegenerative diseases characterized by protein… (More)
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Highly Cited
2002
Highly Cited
2002
The mechanisms of pathology for the family of polyglutamine disease proteins are unknown; however, recently it was shown that… (More)
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Highly Cited
1997
Highly Cited
1997
The mechanism of neurodegeneration in CAG/polyglutamine repeat expansion diseases is unknown but is thought to occur at the… (More)
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