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Aspartate Carbamoyltransferase

Known as: Carbamoyl-phosphate:L-aspartate carbamoyltransferase, Carbamoyltransferase, Aspartate, Aspartate Carbamoyltransferase [Chemical/Ingredient] 
An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme… Expand
National Institutes of Health

Related topics

Related topics

9 relations

Narrower (2)

CAD trifunctional enzymecarbamoyl phosphate synthase-aspartatecarbamoyl transferase complex
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
Coordinating Metabolism Growth factors help to coordinate metabolism with growth in part by stimulating the activity of the… Expand
Highly Cited
1993
Highly Cited
1993
The Escherichia coli K-12 "wild types" W3110 and MG1655 have an rph frameshift mutation that leads to pyrimidine starvation due to low pyrE expression levels
  • K. Jensen
  • Journal of bacteriology
  • 1993
    • Corpus ID: 20572919
The widely used and closely related Escherichia coli "wild types" W3110 and MG1655, as well as their common ancestor W1485… Expand
Highly Cited
1989
Highly Cited
1989
Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.
It has been hypothesized that genomic fluidity is an important component of tumorigenesis. Previous studies described the… Expand
Review
1980
Review
1980
Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis.
  • M. E. Jones
  • Annual review of biochemistry
  • 1980
    • Corpus ID: 41168995
PERSPECfIVES AND SUMMARY 253 INTRODUCfION 256 GENES AND PROTEIN PRODUCfS 257 Drosophila 257 Mammals 258 Multienzyme pyr1-3 258… Expand
Highly Cited
1979
Highly Cited
1979
Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.
Mutant Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a transition state analog inhibitor of aspartate… Expand
Highly Cited
1970
Highly Cited
1970
Use of dimethyl suberimidate, a cross-linking reagent, in studying the subunit structure of oligomeric proteins.
Amidination of aldolase, glyceraldehyde-3-phosphate dehydrogenase, tryptophan synthetase B protein, L-arabinose isomerase, and… Expand
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Highly Cited
1968
Highly Cited
1968
Allosteric interactions in aspartate transcarbamylase. II. Evidence for different conformational states of the protein in the presence and absence of specific ligands.
Highly Cited
1967
Highly Cited
1967
The purification of aspartate transcarbamylase of Escherichia coli and separation of its protein subunits.
Abstract Aspartate transcarbamylase, a regulatory enzyme from Escherichia coli, has been prepared by a procedure which yields… Expand
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Highly Cited
1965
Highly Cited
1965
Distinct subunits for the regulation and catalytic activity of aspartate transcarbamylase.
Abstract : The communication presents direct physiochemical studies concerning the enzyme aspartate transcarbamylase (ATCase) in… Expand
Highly Cited
1962
Highly Cited
1962
The enzymology of control by feedback inhibition.
One way in which an organism controls its biosynthetic path- ways is by feedback inhibition. This control adjusts the rate of… Expand
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