Arene Oxide Detoxification Defect

 
National Institutes of Health

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Inborn Errors of Metabolism

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Highly Cited
2011
Highly Cited
2011
Metal complexes as DNA intercalators.
DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its derivatives. Lerman in 1961 first… (More)
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2011
2011
Organometallic ruthenium(II) arene compounds with antiangiogenic activity.
The antimetastatic ruthenium(II) compounds [Ru(η(6)-p-cymene)Cl(2)(PTA)] (PTA = 1,3,5-triaza-7-phosphaadamantane) (RAPTA-C) and… (More)
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2009
2009
Palladium- and copper-catalyzed arylation of carbon-hydrogen bonds.
The transition-metal-catalyzed functionalization of C-H bonds is a powerful method for generating carbon-carbon bonds. Although… (More)
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Review
2009
Review
2009
Unusual DNA binding modes for metal anticancer complexes.
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form… (More)
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2005
2005
Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity.
We analyzed DNA duplexes modified at central guanine residues by monofunctional Ru(II) arene complexes [(eta(6)-arene)Ru(II)(en… (More)
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2005
2005
The Gravettian burial known as the Prince ( “ Il Principe ” ) : new evidence for his age and diet
“Il Principe” (the Prince) is the nickname given to a spectacular Mid Upper Palaeolithic (Gravettian) burial discovered at Arene… (More)
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2003
2003
DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media.
Modifications of natural DNA in a cell-free medium by antitumor monodentate Ru(II) arene compounds of the general formula [(eta(6… (More)
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2002
2002
In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer
Ruthenium complexes offer the potential of reduced toxicity, a novel mechanism of action, non-cross resistance and a different… (More)
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1996
1996
Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s).
The metabolism of carbamazepine (CBZ) and its major metabolite in humans, carbamazepine 10,11-epoxide (CBZ-E), was examined in… (More)
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1987
1987
Evidence of spinal tuberculosis at the beginning of the fourth millennium BC from Arene Candide cave (Liguria, Italy).
This paper describes tuberculosislike lesions affecting the spine of Neolithic skeleton found in Arene Candide cave (Liguria… (More)
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