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Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes.
The cytotoxic activity of the carboxylic acids and di (5-8) and triphenyltin(IV) complexes was tested against tumor cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear cells PBMC. Expand
Synthesis and biological applications of ionic triphenyltin(IV) chloride carboxylate complexes with exceptionally high cytotoxicity.
Compound 4 is found to induce apoptosis via extrinsic pathways on DLD-1 cell lines, probably by accumulation of caspases 2, 3 and 8, and seems to cause disturbances in G1 and G2/M phases in cell cycle of DLD -1 cell line. Expand
New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies.
Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design and are potential "new keys for old locks" which open up an exciting field of research for well-known, but challenging important therapeutic substrates. Expand
Ruthenium(II) p-cymene complex bearing 2,2'-dipyridylamine targets caspase 3 deficient MCF-7 breast cancer cells without disruption of antitumor immune response.
Importantly, complex 1 applied in concentrations which were effective against tumor cells did not affect immune cell viability, nor did exert a general immunosuppressive effect on cytokine production, thus, beneficial characteristics of 1 might contribute to the overall therapeutic properties of the complex. Expand
Anticancer activity of dinuclear gallium(III) carboxylate complexes.
The cytotoxic activity of the gallium(III) complexes (1-5) was tested against human tumor cell lines 8505C anaplastic thyroid cancer, A253 head and neck tumor, A549 lung carcinoma, A2780 ovarian cancer, DLD-1 colon carcinoma and compared with that of cisplatin. Expand
Ortho-carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors.
Preliminary biological studies gave an interesting insight into the validity of employing carbaboranes as pharmacophores and only the ortho-carbaborane derivatives were active compounds. Expand
Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors.
Structural-activity analysis indicates that substituted phenyl rings are tolerated as ester components in inorganic ortho- and meta-carbaborane moieties and investigates the validity of using these boron clusters as drug entities. Expand
Representation of configuration in coordination polyhedra and the extension of current methodology to coordination numbers greater than six (IUPAC Technical Report)
Established IUPAC recommendations for the representation of configuration are reviewed briefly, and then methodologies are examined for dealing with regular polyhedra that are typically used whenExpand
Hexaphosphanylamine Ligands: 1,1,4,7,10,10-Hexakis(diphenylphosphanyl)-triethylenetetramine Complexes of Chromium, Molybdenum, and Tungsten†
The oligophosphanylamine ligand 1,1,4,7,10,10-hexakis(diphenylphosphanyl)triethylenetetramine (1) was obtained from the reaction of triethylenetetramine with six equivalents ofExpand