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Apical Ectodermal Ridge

A thickened surface layer of ectodermal cells found at the end of each limb bud in the developing embryo.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Senescence is a form of cell-cycle arrest linked to tumor suppression and aging. However, it remains controversial and has not… Expand
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Highly Cited
2002
Highly Cited
2002
To determine the role of fibroblast growth factor (FGF) signalling from the apical ectodermal ridge (AER), we inactivated Fgf4… Expand
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Highly Cited
2001
Highly Cited
2001
We demonstrate that signaling via the bone morphogenetic protein receptor IA (BMPR-IA) is required to establish two of the three… Expand
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Highly Cited
1999
Highly Cited
1999
The p63 gene, a homologue of the tumour-suppressor p53 (refs 1–5), is highly expressed in the basal or progenitor layers of many… Expand
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Highly Cited
1999
Highly Cited
1999
The interactions between fibroblast growth factors (FGF) and their receptors have important roles in mediating mesenchymal… Expand
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Highly Cited
1999
Highly Cited
1999
The apical ectodermal ridge (AER), a transient specialized epithelium at the distal limb tip, is essential for vertebrate… Expand
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Highly Cited
1998
Highly Cited
1998
Fgf-10-deficient mice (Fgf-10(-/-)) were generated to determine the role(s) of Fgf-10 in vertebrate development. Limb bud… Expand
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Highly Cited
1997
Highly Cited
1997
We wish to understand how limbs are positioned with respect to the dorso-ventral axis of the body in vertebrate embryos, and how… Expand
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Highly Cited
1994
Highly Cited
1994
Proper limb growth and patterning requires signals from the zone of polarizing activity in the posterior mesoderm and from the… Expand
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Highly Cited
1993
Highly Cited
1993
The apical ectodermal ridge plays a key role in limb development. We show that recombinant FGF-4 can substitute for the ridge to… Expand
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