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Apical Ectodermal Ridge

A thickened surface layer of ectodermal cells found at the end of each limb bud in the developing embryo.
National Institutes of Health

Related topics

Related topics

1 relation
Limb Buds

Papers overview

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Highly Cited
2006
Highly Cited
2006
Adhesion between cells, diffusion of growth factors, and elasticity of the AER produce the paddle shape of the chick limb.
Highly Cited
1995
Highly Cited
1995
A Xenopus distal-less gene in transgenic mice: conserved regulation in distal limb epidermis and other sites of epithelial-mesenchymal interaction.
In this paper, we show the conserved regulation of the homeodomain gene Distal-less-3 (Dlx-3) by analyzing the expression of a… 
Highly Cited
1992
Highly Cited
1992
Insulin-like growth factor I and II and insulin-like growth factor binding protein-2 RNAs are expressed in adjacent tissues within rat embryonic and fetal limbs.
Highly Cited
1989
Highly Cited
1989
The limb deformity gene is required for apical ectodermal ridge differentiation and anteroposterior limb pattern formation.
To gain insight into the role of the limb deformity (ld) gene in limb morphogenesis, we examined the morphologic details of early… 
Highly Cited
1987
Highly Cited
1987
The differentiation of normal and muscle-free distal chick limb bud mesenchyme in micromass culture.
1984
1984
Myogenic cell movement in the developing avian limb bud in presence and absence of the apical ectodermal ridge (AER).
Fragments of quail wing bud containing myogenic cells of somitic origin and fragments of quail sphlanchopleural tissue were… 
Highly Cited
1977
Highly Cited
1977
Ultrastructural analysis of the apical ectodermal ridge during vertebrate limb morphogenesis: II. Gap junctions as distinctive ridge structures common to birds and mammals
The fine structure of the apical ectodermal ridge of five phylogenetically divergent orders of mammals and two orders of birds… 
Highly Cited
1973
Highly Cited
1973
A description of chick wing bud development and a model of limb morphogenesis.
Highly Cited
1967
Highly Cited
1967
Limb development in the polydactylous talpid3 mutant of the fowl
The three groups of abnormal chick embryos known as talpids show a common pattern of remarkably widespread pleiotropic… 
Highly Cited
1965
Highly Cited
1965
AN AUTORADIOGRAPHIC STUDY OF THE UPTAKE OF S35-SULFATE DURING THE DIFFERENTIATION OF LIMB BUD CARTILAGE.
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