Antibody-Directed Enzyme Prodrug Therapy

Known as: ADEPT 
A systemic therapy which ensures that a specific prodrug is not converted into the active moiety anywhere but at the sites where the enzyme-linked… (More)
National Institutes of Health

Papers overview

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2005
2005
PURPOSE Antibody-directed enzyme prodrug therapy (ADEPT) requires highly selective antibody-mediated delivery of enzyme to tumor… (More)
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Review
2001
Review
2001
The selective activation of prodrug(s) in tumor tissues by exogenous enzyme(s) for cancer therapy can be accomplished by several… (More)
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2001
2001
Antibody-directed enzyme prodrug therapy (ADEPT) has displayed antitumor activity in animal models and clinical trials. We… (More)
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1999
1999
The irregular nature of solid tumor vasculature produces a heterogeneous distribution of antibody-targeted therapies within the… (More)
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1997
1997
Antibody-directed enzyme prodrug therapy (ADEPT) was administered to ten patients in a phase I clinical trial. The aim was to… (More)
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1996
1996
Antibody-directed enzyme prodrug therapy (ADEPT) aims at the specific activation of a prodrug by an enzyme-immunoconjugate… (More)
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1996
1996
Purpose. Immuno-enzymosomes are tumor-specific immunoliposomes bearing enzymes on their surface. These enzymes are capable of… (More)
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1994
1994
Antibody directed enzyme prodrug therapy (ADEPT) has been studied as a two- and three-phase system in which an antibody to a… (More)
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1991
1991
Following an extensive series of studies in nude mice with human xenografts a pilot scale clinical trial of antibody directed… (More)
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Review
1990
Review
1990
Antibody-directed enzyme prodrug therapy (ADEPT) has been studied in a human ovarian carcinoma xenograft grown subcutaneously in… (More)
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