Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 218,393,623 papers from all fields of science
Search
Sign In
Create Free Account
Antibody-Directed Enzyme Prodrug Therapy
Known as:
ADEPT
A systemic therapy which ensures that a specific prodrug is not converted into the active moiety anywhere but at the sites where the enzyme-linked…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
1 relation
Broader (1)
Biological Immunotherapy
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Antibody-directed enzyme prodrug therapy (ADEPT)
Sur Sharma
,
J. Boden
,
C. Springer
,
P. Burke
,
K. Bagshawe
Cell Biophysics
2007
Corpus ID: 11222055
Antibody-directed enzyme prodrug therapy (ADEPT) has been studied in a human ovarian carcinoma xenograft grown subcutaneously in…
Expand
Review
2006
Review
2006
Antibody-directed enzyme prodrug therapy (ADEPT) for cancer
K. Bagshawe
Expert Review of Anticancer Therapy
2006
Corpus ID: 2749415
Antibody-directed enzyme prodrug therapy was conceived as a means of restricting the action of cytotoxic drugs to tumor sites…
Expand
Highly Cited
2005
Highly Cited
2005
Sustained tumor regression of human colorectal cancer xenografts using a multifunctional mannosylated fusion protein in antibody-directed enzyme prodrug therapy.
Sur Sharma
,
R. Pedley
,
+9 authors
K. Chester
Clinical Cancer Research
2005
Corpus ID: 1450262
PURPOSE Antibody-directed enzyme prodrug therapy (ADEPT) requires highly selective antibody-mediated delivery of enzyme to tumor…
Expand
Review
2004
Review
2004
Antibody-directed enzyme prodrug therapy (ADEPT) for cancer
K. Bagshawe
,
Sur Sharma
,
R. Begent
Expert Opinion on Biological Therapy
2004
Corpus ID: 34298893
Antibody-directed enzyme prodrug therapy (ADEPT) aims to restrict the cytotoxic action to tumour sites. The obstacles to achieve…
Expand
Review
2001
Review
2001
Strategies for enzyme/prodrug cancer therapy.
G. Xu
,
H. McLeod
Clinical Cancer Research
2001
Corpus ID: 18209573
The selective activation of prodrug(s) in tumor tissues by exogenous enzyme(s) for cancer therapy can be accomplished by several…
Expand
Review
1997
Review
1997
Antibody-directed enzyme prodrug therapy (ADEPT): a review.
I. Niculescu-Duvaz
,
C. Springer
Advanced Drug Delivery Reviews
1997
Corpus ID: 46653597
1995
1995
Antibody-Directed Enzyme Prodrug Therapy
D. J. Knox
,
T. Connors
Clinical Immunotherapeutics
1995
Corpus ID: 5382964
Antibody-directed enzyme prodrug therapy (ADEPT) is a new approach to the treatment of solid cancers. In ADEPT, an antibody (or…
Expand
Review
1994
Review
1994
Antibody directed enzyme prodrug therapy (ADEPT). A review of some theoretical, experimental and clinical aspects.
K. Bagshawe
,
S. Sharma
,
C. Springer
,
G. Rogers
Annals of Oncology
1994
Corpus ID: 21050036
The concept of generating cytotoxic agents from non-toxic prodrugs at tumour sites by antibody vectored enzyme introduces a wide…
Expand
Highly Cited
1991
Highly Cited
1991
Antibody directed enzyme prodrug therapy (ADEPT): clinical report.
K. Bagshawe
,
Sur Sharma
,
+6 authors
R. Sherwood
Disease Markers
1991
Corpus ID: 29215011
Following an extensive series of studies in nude mice with human xenografts a pilot scale clinical trial of antibody directed…
Expand
Highly Cited
1991
Highly Cited
1991
Antibody directed enzyme prodrug therapy (ADEPT): a three phase system.
Sur Sharma
,
K. Bagshawe
,
+6 authors
R. Sherwood
Disease Markers
1991
Corpus ID: 12257907
Monoclonal anti-CEA antibody, A5B7, and its fragments conjugated to CPG2 localize to a peak concentration in the LS174T…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE