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Anti-TIM-3 Monoclonal Antibody MBG453

Known as: Anti-TIM3 Checkpoint Inhibitor MBG453, MBG 453, MBG453 
An inhibitor of the inhibitory T-cell receptor T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; hepatitis A virus cellular… 
National Institutes of Health

Related topics

Related topics

1 relation
antigen binding

Papers overview

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Highly Cited
2019
Highly Cited
2019
Phase Ib Study of the Anti-TIM-3 Antibody MBG453 in Combination with Decitabine in Patients with High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)
Co-senior authors Andrew Brunner and Andrew H. Wei contributed equally to this work Background: MBG453 is a high-affinity… 
Review
2018
Review
2018
Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The tumour microenvironment (TME) in PDA is… 
2017
2017
Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects
Abstract Chronic osteomyelitis and infected bone defects are substantial challenges faced by orthopaedic surgeons. In this study… 
Review
2017
Review
2017
Function and mechanism of mesoporous bioactive glass adsorbed epidermal growth factor for accelerating bone tissue regeneration
Mesoporous bioactive glass (MBG) has been demonstrated to play a vital role in bone tissue engineering due to its bioactivity… 
2014
2014
Passive immunization against marinobufagenin attenuates renal fibrosis and improves renal function in experimental renal disease.
BACKGROUND We have shown that the cardiotonic steroid marinobufagenin (MBG) is elevated in clinical and experimental renal… 
2008
2008
Marinobufagenin inhibits proliferation and migration of cytotrophoblast and CHO cells.
2008
2008
In situ SAXRD study of sol-gel induced well-ordered mesoporous bioglasses for drug delivery.
In this work, two systems of mesoporous bioglasses (MBGs) were sol-gel derived using block copolymer pluronic F127 and P123… 
Highly Cited
2007
Highly Cited
2007
Mean blood glucose compared with HbA1c in the prediction of cardiovascular disease in patients with type 1 diabetes
Aims/hypothesisIt is not known whether mean blood glucose (MBG) predicts the risk of macrovascular complications in diabetes any… 
2007
2007
The potential of kales as a promising vegetable crop
Sixty varieties of kale (Brassica oleracea acephala group) from Galicia (northwestern Spain) were evaluated in two locations… 
Highly Cited
2001
Highly Cited
2001
The role of the Type I interferon response in the resistance of mice to filovirus infection.
  • M. Bray
  • Journal of General Virology
  • 2001
  • Corpus ID: 35674319
Adult immunocompetent mice inoculated with Ebola (EBO) or Marburg (MBG) virus do not become ill. A suckling-mouse-passaged… 
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