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Anti-Idiotype Vaccine

A vaccine made of antibodies that see other antibodies as the antigen and bind to it. Anti-idiotype vaccines can stimulate the body to produce… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
A Phase I Study of the Anti‐Idiotype Vaccine Racotumomab in Neuroblastoma and Other Pediatric Refractory Malignancies
Pediatric neuroectodermal malignancies express N‐glycolylated gangliosides including N‐glycolyl GM3 (NeuGcGM3) as targets for… 
Highly Cited
2014
Highly Cited
2014
A Randomized, Multicenter, Placebo-Controlled Clinical Trial of Racotumomab-Alum Vaccine as Switch Maintenance Therapy in Advanced Non–Small Cell Lung Cancer Patients
Purpose: Racotumomab-alum is an anti-idiotype vaccine targeting the NeuGcGM3 tumor-associated ganglioside. This clinical trial… 
2012
2012
Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides – preclinical and clinical data
Neu-glycolyl (NeuGc)-containing gangliosides are attractive targets for immunotherapy with anti-idiotype mAbs, because these… 
Highly Cited
2007
Highly Cited
2007
1E10 anti-idiotype vaccine in non-small cell lung cancer: Experience in stage IIIb/IV patients.
Conventional treatment of non-small cell lung cancer (NSCLC) has apparently reached a plateau of effectiveness in improving the… 
Highly Cited
2007
Highly Cited
2007
Active immunotherapy with 1E10 anti-idiotype vaccine in patients with small cell lung cancer: Report of a phase I trial
1E10 is an anti-idiotype murine monoclonal antibody (Ab2 MAb) specific to an Ab1 MAb which reacts with NeuGc-containing… 
Review
2004
Review
2004
Vaccine therapy for small cell lung cancer.
One novel approach to the treatment of lethal residual disease in patients with small cell lung cancer (SCLC) relies on the… 
2003
2003
Immunostimulatory CpG oligonucleotides enhance the immune response of anti-idiotype vaccine that mimics carcinoembryonic antigen
Abstract. We have developed and characterized a monoclonal anti-idiotype (Id) antibody, designated 3H1, which mimics a specific… 
Review
2002
Review
2002
Cancer vaccines: an update with special focus on ganglioside antigens.
Vaccine development is one of the most promising and exciting fields in cancer research; numerous approaches are being studied to… 
2000
2000
Cancer vaccines: single-epitope anti-idiotype vaccine versus multiple-epitope antigen vaccine
Abstract In this study, we compared the immunogenicity and tumor-protective activity of anti-idiotypic antibodies mimicking a… 
Highly Cited
1997
Highly Cited
1997
Immunological responses to the tumor-associated antigen CA125 in patients with advanced ovarian cancer induced by the murine monoclonal anti-idiotype vaccine ACA125.
We have generated an immunoglobulin G1 (IgG1) murine monoclonal anti-idiotype antibody (Ab2) designated ACA125, which mimics a… 
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