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Anti-CEA BiTE Monoclonal Antibody MEDI-565, Human

Known as: MEDI-565 
National Institutes of Health

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Anti-CEA BiTE Monoclonal Antibody AMG211MT111

Papers overview

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2015
2015
Phase I study of AMG 211/MEDI-565 administered as continuous intravenous infusion for relapsed/refractory gastrointestinal (GI) adenocarcinoma.
TPS3097 Background: The bispecific CD19-directed CD3 T-cell engager (BiTE(R)) blinatumomab was recently approved by FDA as single… 
2012
2012
The CEA/CD3-Bispecific Antibody MEDI-565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA
MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with… 
2012
2012
Abstract 3524: A novel approach to targeting mutated colorectal adenocarcinomas with T cell-engaging CEA/CD3-bispecific BiTE investigational antibody MEDI-565
Colorectal cancer (CRC) cells can harbor somatic mutations with strong impact on cancer cell signaling that limit the… 
2011
2011
In vitro MABEL approach for nonclinical safety assessment of MEDI-565 ( MT 111 ) , a novel CEA / CD 3-bispecific single-chain BiTE antibody
the changing environment of monoclonal antibody (mAb) development is impacting on the cost of drug development and the use of… 
2010
2010
Abstract 2584: The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope present in the full-length but not a short splice variant of CEA
MEDI-565 (MT111) is a novel bispecific single-chain antibody of the BiTE (Bi-specific T-cell engager) class that transiently… 
2010
2010
Abstract 5338: Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T cell killing mediated by CEA/CD3-bispecific T cell-engaging BiTE antibody
Carcinoembryonic antigen (CEA; CD66e, CEACAM5) is a well-characterized tumor-associated antigen that is frequently and uniformly… 
2010
2010
Abstract 5625:In vitroandin vivopharmacology of MEDI-565 (MT111), a novel CEA/CD3-bispecific single-chain BiTE antibody in development for the treatment of gastrointestinal adenocarcinomas
MEDI-565 (MT111) is a novel bispecific single-chain antibody of the BiTE (Bispecific T cell engager) class that transiently links… 
Highly Cited
2009
Highly Cited
2009
Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody
Background:Novel technologies to redirect T-cell killing against cancer cells are emerging. We hypothesised that metastatic human… 
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