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Anti-CEA BiTE Monoclonal Antibody MEDI-565, Human
Known as:
MEDI-565
National Institutes of Health
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Related topics
Related topics
2 relations
Anti-CEA BiTE Monoclonal Antibody AMG211
MT111
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Phase 1 Dose Escalation Study of MEDI-565, a Bispecific T-Cell Engager that Targets Human Carcinoembryonic Antigen, in Patients With Advanced Gastrointestinal Adenocarcinomas.
M. Pishvaian
,
M. Morse
,
+7 authors
C. Denlinger
Clinical colorectal cancer
2016
Corpus ID: 46562085
2016
2016
Phase 1 dose escalation study of MEDI-565, a bispecific T-cell engager that targets human carcinoembryonic antigen (CEA), in patients with advanced gastrointestinal (GI) adenocarcinomas.
M. Pishvaian
,
M. Morse
,
+6 authors
C. Denlinger
2016
Corpus ID: 79433096
320 Background: MEDI-565, a bispecific single-chain antibody, targets human CEA on tumor cells and the CD3 epsilon subunit of the…
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2015
2015
Phase I study of AMG 211/MEDI-565 administered as continuous intravenous infusion for relapsed/refractory gastrointestinal (GI) adenocarcinoma.
E. Vries
,
V. Heinemann
,
+12 authors
S. Stienen
2015
Corpus ID: 196480227
TPS3097 Background: The bispecific CD19-directed CD3 T-cell engager (BiTE(R)) blinatumomab was recently approved by FDA as single…
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Highly Cited
2014
Highly Cited
2014
CEA/CD3 bispecific antibody MEDI-565/AMG 211 activation of T cells and subsequent killing of human tumors is independent of mutations commonly found in colorectal adenocarcinomas
M. Oberst
,
Stacy Fuhrmann
,
+7 authors
S. Hammond
mAbs
2014
Corpus ID: 12964975
Individual or combinations of somatic mutations found in genes from colorectal cancers can redirect the effects of chemotherapy…
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2012
2012
The CEA/CD3-Bispecific Antibody MEDI-565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA
Li Peng
,
M. Oberst
,
+10 authors
S. Hammond
PLoS ONE
2012
Corpus ID: 12981150
MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with…
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2012
2012
Abstract 3524: A novel approach to targeting mutated colorectal adenocarcinomas with T cell-engaging CEA/CD3-bispecific BiTE investigational antibody MEDI-565
M. Oberst
,
Stacy Fuhrmann
,
+7 authors
S. Hammond
2012
Corpus ID: 72081243
Colorectal cancer (CRC) cells can harbor somatic mutations with strong impact on cancer cell signaling that limit the…
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Highly Cited
2010
Highly Cited
2010
Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody
T. Osada
,
D. Hsu
,
+5 authors
M. Morse
British Journal of Cancer
2010
Corpus ID: 16936669
Background:Novel technologies to redirect T-cell killing against cancer cells are emerging. We hypothesised that metastatic human…
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2010
2010
Abstract 2584: The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope present in the full-length but not a short splice variant of CEA
Li Peng
,
M. Oberst
,
+12 authors
S. Hammond
2010
Corpus ID: 57089332
MEDI-565 (MT111) is a novel bispecific single-chain antibody of the BiTE (Bi-specific T-cell engager) class that transiently…
Expand
2010
2010
Abstract 5338: Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T cell killing mediated by CEA/CD3-bispecific T cell-engaging BiTE antibody
T. Osada
,
D. Hsu
,
+5 authors
M. Morse
2010
Corpus ID: 72922889
Carcinoembryonic antigen (CEA; CD66e, CEACAM5) is a well-characterized tumor-associated antigen that is frequently and uniformly…
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2010
2010
Abstract 5625:In vitroandin vivopharmacology of MEDI-565 (MT111), a novel CEA/CD3-bispecific single-chain BiTE antibody in development for the treatment of gastrointestinal adenocarcinomas
Stacy Fuhrmann
,
M. Amann
,
+12 authors
S. Hammond
2010
Corpus ID: 71766778
MEDI-565 (MT111) is a novel bispecific single-chain antibody of the BiTE (Bispecific T cell engager) class that transiently links…
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