Angiozyme
National Institutes of Health
Papers overview
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Serum and plasma levels of vascular endothelial growth factor (VEGF) correlate with prognosis in patients with metastatic breast…
Purpose: This study intended to determine the maximum tolerated dose, safety, pharmacokinetic variables, clinical response, and…
PurposeRPI.4610 (ANGIOZYME) is a chemically stabilized ribozyme targeting vascular endothelial growth factor receptor 1. The…
Several inhibitors of angiogenesis are being developed for the treatment of cancer. One dominant strategy involves disruption of…
The discovery of ribozymes by Cech and Altman has fundamentally changed the view of the function of RNA in chemistry, biology…
The potential acute toxicity of a ribozyme (ANGIOZYME) targeting the flt-1 vascular endothelial growth factor (VEGF) receptor…
A significant amount of research has been devoted to the chemical stabilization of synthetic ribozymes, in part, so that…