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Angiozyme

 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Catalytic RNAanti-FLT-1 ribozyme

Narrower (1)

Ribozyme RPI.4610

Papers overview

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2012
2012
An open-label, phase 2 trial of RPI.4610 (Angiozyme) in the treatment of metastatic breast cancer.
BACKGROUND Serum and plasma levels of vascular endothelial growth factor (VEGF) correlate with prognosis in patients with… Expand
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2005
2005
A phase I clinical trial of a ribozyme-based angiogenesis inhibitor targeting vascular endothelial growth factor receptor-1 for patients with refractory solid tumors.
PURPOSE This study intended to determine the maximum tolerated dose, safety, pharmacokinetic variables, clinical response, and… Expand
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2004
2004
Safety and pharmacokinetic study of RPI.4610 (ANGIOZYME), an anti-VEGFR-1 ribozyme, in combination with carboplatin and paclitaxel in patients with advanced solid tumors
PurposeRPI.4610 (ANGIOZYME) is a chemically stabilized ribozyme targeting vascular endothelial growth factor receptor 1. The… Expand
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Review
2001
Review
2001
Angiozyme: A Novel angiogenesis inhibitor
Several inhibitors of angiogenesis are being developed for the treatment of cancer. One dominant strategy involves disruption of… Expand
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Review
2000
Review
2000
Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics.
The discovery of ribozymes by Cech and Altman has fundamentally changed the view of the function of RNA in chemistry, biology… Expand
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2000
2000
Acute toxicology and pharmacokinetic assessment of a ribozyme (ANGIOZYME) targeting vascular endothelial growth factor receptor mRNA in the cynomolgus monkey.
The potential acute toxicity of a ribozyme (ANGIOZYME) targeting the flt-1 vascular endothelial growth factor (VEGF) receptor… Expand
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2000
2000
Ribozyme pharmacokinetic screening for predicting pharmacodynamic dosing regimens.
A significant amount of research has been devoted to the chemical stabilization of synthetic ribozymes, in part, so that… Expand
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